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蛛网膜下腔出血:流行病学、诊断、治疗及预后

Subarachnoid hemorrhage: epidemiology, diagnosis, management, and outcome.

作者信息

Bonita R, Thomson S

出版信息

Stroke. 1985 Jul-Aug;16(4):591-4. doi: 10.1161/01.str.16.4.591.

Abstract

A population-based study of primary subarachnoid hemorrhage in Auckland (population 829,454), New Zealand, identified 180 cases in a two-year period. This represented an age adjusted incidence rate of 10.5 and 18.3 per 100,000 for men and women respectively. Sixty-eight percent of all cases had a proven intracranial aneurysm or arteriovenous malformation, 15% had negative angiographic findings and in the remaining 17%, the presence or absence of a localized lesion was unknown since neither angiography nor autopsy were performed. Twenty-six patients (15%) died before hospitalization and a further 36 patients (20%) died within 48 hours of onset. Only 94 patients (53% of all patients registered) were fit enough to undergo angiography. A surgical operation was carried out on 60 of the 68 patients in whom an aneurysm was confirmed at angiography. The overall case fatality rate was 36% within the first 48 hours, 43% in the first week and 57% at both six months and one year. The high early case fatality rates are similar to those found in previous population-based studies, suggesting that despite the major advances to individual patients from technological advances, the potential contribution of hospital management to the reduction of subarachnoid haemorrhage mortality rates is likely to be limited.

摘要

一项针对新西兰奥克兰市(人口829,454)原发性蛛网膜下腔出血的基于人群的研究,在两年时间内确定了180例病例。这相当于年龄调整后的发病率,男性为每10万人10.5例,女性为每10万人18.3例。所有病例中,68%经证实患有颅内动脉瘤或动静脉畸形,15%血管造影结果为阴性,其余17%由于既未进行血管造影也未进行尸检,局部病变的有无尚不清楚。26名患者(15%)在住院前死亡,另有36名患者(20%)在发病后48小时内死亡。只有94名患者(占所有登记患者的53%)身体状况足以接受血管造影。在血管造影证实患有动脉瘤的68名患者中,有60名接受了手术。总体病死率在发病后48小时内为36%,第一周为43%,六个月和一年时均为57%。早期的高病死率与先前基于人群的研究结果相似,这表明尽管技术进步对个体患者有重大进展,但医院管理对降低蛛网膜下腔出血死亡率的潜在贡献可能有限。

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