Berkowitz R S, Cramer D W, Bernstein M R, Cassells S, Driscoll S G, Goldstein D P
Am J Obstet Gynecol. 1985 Aug 15;152(8):1016-20. doi: 10.1016/0002-9378(85)90550-2.
Demographic, reproductive, and dietary histories for 90 white women with complete molar pregnancy were compared in a multivariate analysis with those of 90 parous controls matched to cases by residence, birth year, and race. Women with molar pregnancy were more likely to have been born outside North America (relative risk = 1.9, p = 0.05), were more likely to have been past age 30 at time of their molar pregnancy (relative risk = 1.6, p = 0.05), and were more likely to have diets deficient in the vitamin A precursor carotene. Women with dietary scores for carotene above the control median had a relative risk for molar pregnancy of 0.6 (p = 0.02). In addition, there was a significant trend for decreasing risk for molar pregnancy with increasing consumption of carotene. Although other nutritional deficiencies in patients with complete molar pregnancy may exist, carotene is a biologically plausible candidate for a nutritional risk factor that could explain the geographic distribution of molar pregnancy.
在一项多变量分析中，对90例患有完全性葡萄胎的白人女性的人口统计学、生育史和饮食史，与90名经产妇对照者进行了比较，这些对照者在居住地、出生年份和种族方面与病例相匹配。患有葡萄胎的女性更有可能出生在北美以外地区（相对风险=1.9，p=0.05），在发生葡萄胎时更有可能超过30岁（相对风险=1.6，p=0.05），并且更有可能饮食中缺乏维生素A前体胡萝卜素。饮食中胡萝卜素得分高于对照中位数的女性患葡萄胎的相对风险为0.6（p=0.02）。此外，随着胡萝卜素摄入量的增加，患葡萄胎的风险有显著下降趋势。虽然完全性葡萄胎患者可能存在其他营养缺乏，但胡萝卜素是一种生物学上合理的营养风险因素候选物，可解释葡萄胎的地理分布。
