Multi-contrast computed tomography atlas of healthy pancreas with dense displacement sampling registration.

PURPOSE

Diverse population demographics can lead to substantial variation in the human anatomy. Therefore, standard anatomical atlases are needed for interpreting organ-specific analyses. Among abdominal organs, the pancreas exhibits notable variability in volumetric morphology, shape, and appearance, complicating the generalization of population-wide features. Understanding the common features of a healthy pancreas is crucial for identifying biomarkers and diagnosing pancreatic diseases.

APPROACH

We propose a high-resolution CT atlas framework optimized for the healthy pancreas. We introduce a deep-learning-based preprocessing technique to extract abdominal ROIs and leverage a hierarchical registration pipeline to align pancreatic anatomy across populations. Briefly, DEEDS affine and non-rigid registration techniques are employed to transfer patient abdominal volumes to a fixed high-resolution atlas template. To generate and evaluate the pancreas atlas, multi-phase contrast CT scans of 443 subjects (aged 15 to 50 years, with no reported history of pancreatic disease) were processed.

RESULTS

The two-stage DEEDS affine and non-rigid registration outperforms other state-of-the-art tools, achieving the highest scores for pancreas label transfer across all phases (non-contrast: 0.497, arterial: 0.505, portal venous: 0.494, delayed: 0.497). External evaluation with 100 portal venous scans and 13 labeled abdominal organs shows a mean Dice score of 0.504. The low variance between the pancreases of registered subjects and the obtained pancreas atlas further illustrates the generalizability of the proposed method.

CONCLUSION

We introduce a high-resolution pancreas atlas framework to generalize healthy biomarkers across populations with multi-contrast abdominal CT. The atlases and the associated pancreas organ labels are publicly available through the Human Biomolecular Atlas Program (HuBMAP).