Biomedical Engineering Graduate Program, University of Calgary, Calgary, AB, Canada.
Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Sci Data. 2020 Feb 17;7(1):56. doi: 10.1038/s41597-020-0379-9.
Normative brain atlases are a standard tool for neuroscience research and are, for example, used for spatial normalization of image datasets prior to voxel-based analyses of brain morphology and function. Although many different atlases are publicly available, they are usually biased with respect to an imaging modality and the age distribution. Both effects are well known to negatively impact the accuracy and reliability of the spatial normalization process using non-linear image registration methods. An important and very active neuroscience area that lacks appropriate atlases is lesion-related research in elderly populations (e.g. stroke, multiple sclerosis) for which FLAIR MRI and non-contrast CT are often the clinical imaging modalities of choice. To overcome the lack of atlases for these tasks and modalities, this paper presents high-resolution, age-specific FLAIR and non-contrast CT atlases of the elderly generated using clinical images.
规范化脑图谱是神经科学研究的标准工具，例如，在对脑形态和功能进行基于体素的分析之前，用于对图像数据集进行空间归一化。尽管有许多不同的图谱可供公开使用，但它们通常偏向于一种成像方式和年龄分布。这两种影响都众所周知，会降低使用非线性图像配准方法进行空间归一化处理的准确性和可靠性。一个非常活跃且缺乏适当图谱的重要神经科学领域是老年人群中的病变相关研究（例如中风、多发性硬化症），对于这些研究，FLAIR MRI 和非对比 CT 通常是临床成像的首选方式。为了克服这些任务和模态缺乏图谱的问题，本文提出了使用临床图像生成的针对老年人的高分辨率、年龄特异性的 FLAIR 和非对比 CT 图谱。
