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细胞诱导的备解素途径激活导致人培养淋巴母细胞样细胞溶解。

Lysis of human cultured lymphoblastoid cells by cell-induced activation of the properdin pathway.

作者信息

Theofilopoulos A N, Perrin L H

出版信息

Science. 1977 Mar 4;195(4281):878-80. doi: 10.1126/science.402691.

DOI:10.1126/science.402691
PMID:402691
Abstract

Human cultured lymphoblastoid cells incubated in normal human serum activate the properdin complement pathway without antibody. However, only cells bearing C3b immune adherence receptors bind components of the properdin complement pathway and undergo lysis. A similar surveillance mechanism may exist in man to limit growth of malignant B cells bearing C3b immune adherence receptors.

摘要

在正常人血清中培养的人淋巴母细胞样细胞可在无抗体的情况下激活备解素补体途径。然而，只有带有C3b免疫黏附受体的细胞才能结合备解素补体途径的成分并发生裂解。人体内可能存在类似的监测机制，以限制带有C3b免疫黏附受体的恶性B细胞的生长。

相似文献

1
Lysis of human cultured lymphoblastoid cells by cell-induced activation of the properdin pathway.细胞诱导的备解素途径激活导致人培养淋巴母细胞样细胞溶解。
Science. 1977 Mar 4;195(4281):878-80. doi: 10.1126/science.402691.
2
Binding of components of the properdin system to cultured human lymphoblastoid cells and B lymphocytes.备解素系统成分与培养的人淋巴母细胞和B淋巴细胞的结合。
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Interaction of human lymphocytes with fluid phase human C3b detected by immunofluorescence.通过免疫荧光检测人淋巴细胞与液相人C3b的相互作用。
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引用本文的文献

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Immunology. 1980 Nov;41(3):535-9.
2
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J Clin Invest. 1983 Jun;71(6):1710-9. doi: 10.1172/jci110925.
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Complement, viruses, and virus-infected cells.补体、病毒与病毒感染细胞。
Springer Semin Immunopathol. 1983;6(4):327-47. doi: 10.1007/BF02116278.
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Synthesis of lipids or lipid-containing macromolecules in tumor cells. Relevance to host defense.肿瘤细胞中脂质或含脂质大分子的合成。与宿主防御的相关性。
Surv Immunol Res. 1983;2(2):122-8. doi: 10.1007/BF02918569.
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Antibody-mediated destruction of virus-infected cells.抗体介导的病毒感染细胞的破坏。
Adv Immunol. 1980;29:209-60. doi: 10.1016/s0065-2776(08)60045-0.
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Inhibition of Epstein-Barr virus (EBV) release from the P3HR-1 Burkitt's lymphoma cell line by a monoclonal antibody against a 200,000 dalton EBV membrane antigen.一种针对200,000道尔顿爱泼斯坦-巴尔病毒（EBV）膜抗原的单克隆抗体对P3HR-1伯基特淋巴瘤细胞系中EBV释放的抑制作用
J Exp Med. 1985 May 1;161(5):1097-111. doi: 10.1084/jem.161.5.1097.
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Persistent complement activation on tumor cells in breast cancer.乳腺癌中肿瘤细胞上持续的补体激活。
Am J Pathol. 1992 May;140(5):1039-43.
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