Zhou Lang, Pan Xiong, Chen Fa-Ju, Peng Mei, Wang Yu, Gao Ming, Yang Li-Shou, Li Liang-Qun, Yang Juan, Yang Xiao-Sheng, Li Qi-Ji
State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Guizhou Medical University, Guiyang, 550014, China; Natural Products Research Center of Guizhou Province, Guiyang, 550014, China.
State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Guizhou Medical University, Guiyang, 550014, China; Natural Products Research Center of Guizhou Province, Guiyang, 550014, China.
Phytochemistry. 2025 Aug;236:114519. doi: 10.1016/j.phytochem.2025.114519. Epub 2025 Apr 23.
Five previously undescribed oxygen-bridged sesquiterpenes (cinnamigones D-H), along with three known analogs, were isolated from the fruits of Cinnamomum migao using an MS/MS-based molecular networking strategy. Their structures were unambiguously elucidated through comprehensive spectroscopic analyses, including HRESIMS, X-ray crystallography, electronic circular dichroism calculations, and comparisons with existing literature data. All isolated compounds feature an oxygen-bridged structural units and a tricyclic framework. In particular, cinnamigone E (2) possesses a rare 6/7/6 tricyclic ring system, with the ring A being a benzene ring. The neuroprotective potential of these compounds was assessed using the N-methyl-d-aspartate (NMDA)-induced injury model in PC12 cells. Compounds 2 and 3 exhibited moderate neuroprotective activity against NMDA-induced neurotoxicity. Furthermore, molecular docking studies revealed that compound 2 bind to the active site of the NMDA receptor through hydrogen bonding and hydrophobic interactions.
