甘油三酯葡萄糖指数相关肥胖指标与焦虑之间的关联：来自2007 - 2012年美国国家健康与营养检查调查的见解

Associations between triglyceride glucose index-related obesity indices and anxiety: Insights from the National Health and Nutrition Examination Survey 2007-2012.

作者信息

Wang Yixi, Wang Haimeng, Cheng Bin, Xia Juan

机构信息

Hospital of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou 510055, China.

出版信息

J Affect Disord. 2025 Aug 1;382:443-452. doi: 10.1016/j.jad.2025.04.134. Epub 2025 Apr 23.

DOI:10.1016/j.jad.2025.04.134

PMID:40280441

Abstract

BACKGROUND

The triglyceride glucose index (TyG), along with its associated obesity indices, including TyG-body mass index (TyG-BMI), TyG-waist-to-height ratio (TyG-WHtR), TyG-waist circumference (TyG-WC), and TyG-weight-adjusted-waist index (TyG-WWI), have become valuable tools for evaluating insulin resistance in metabolic diseases. Few researches explored their links with anxiety.

METHODS

This observational study leveraged data from the National Health and Nutrition Examination Survey (2007-2012), analyzing 6726 participants to investigate the correlations between TyG-related indices and anxiety using multivariable logistic regression, subgroup analysis, and curve fitting.

RESULTS

After adjusting for confounders, significant positive correlations were identified between TyG, TyG-WWI, and anxious days [0.792 (0.262, 1.322); 0.033 (0.003, 0.063)]. These findings were reinforced when TyG-related indices were categorized into quartiles. Positive associations were further observed between TyG and anxiety state [1.243 (1.076, 1.437)], which was consistent across quartile groupings. Subgroup analyses revealed that racial stratification significantly influenced the relationship between TyG, TyG-BMI, TyG-WHtR, TyG-WC, TyG-WWI and anxious days. Gender stratification significantly influenced the relationship between TyG and anxiety state. Linear associations were established between TyG and anxious days, anxiety state with regression coefficients of 0.873 and 1.254 respectively. Non-linear relationships and threshold effects were detected, with inflection points at 187.731, 3.040, 725.288, and 104.011 (for TyG-BMI, TyG-WHtR, TyG-WC, TyG-WWI with anxious days) and 188.677, 3.059, 730.251, and 103.869 (for TyG-BMI, TyG-WHtR, TyG-WC, TyG-WWI with anxiety state).

CONCLUSIONS

These results enhance our understanding of relationships between TyG-related indices and anxiety, providing valuable insights for the prevention and management of obesity and anxiety.

摘要

背景

甘油三酯葡萄糖指数（TyG）及其相关的肥胖指数，包括TyG体重指数（TyG-BMI）、TyG腰高比（TyG-WHtR）、TyG腰围（TyG-WC）和TyG体重校正腰围指数（TyG-WWI），已成为评估代谢性疾病中胰岛素抵抗的重要工具。很少有研究探讨它们与焦虑之间的联系。

方法

这项观察性研究利用了美国国家健康与营养检查调查（2007 - 2012年）的数据，分析了6726名参与者，使用多变量逻辑回归、亚组分析和曲线拟合来研究TyG相关指数与焦虑之间的相关性。

结果

在调整混杂因素后，发现TyG、TyG-WWI与焦虑天数之间存在显著正相关[0.792（0.262，1.322）；0.033（0.003，0.063）]。当将TyG相关指数分为四分位数时，这些发现得到了加强。还进一步观察到TyG与焦虑状态之间存在正相关[1.243（1.076，1.437）]，在四分位数分组中都是一致的。亚组分析显示，种族分层显著影响TyG、TyG-BMI、TyG-WHtR、TyG-WC、TyG-WWI与焦虑天数之间的关系。性别分层显著影响TyG与焦虑状态之间的关系。TyG与焦虑天数、焦虑状态之间建立了线性关联，回归系数分别为0.873和1.254。检测到非线性关系和阈值效应，拐点分别为187.731、3.040、725.288和104.011（针对TyG-BMI、TyG-WHtR、TyG-WC、TyG-WWI与焦虑天数）以及188.677、3.059、730.251和103.869（针对TyG-BMI、TyG-WHtR、TyG-WC、TyG-WWI与焦虑状态）。