Nastasia Șerban, Nenciu Adina Elena, Russu Manuela Cristina, Neacșu Adrian Valeriu, Ceaușu Iuliana, Achim Nicoleta Adelina
Department of Obstetrics and Gynecology, Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Department of Obstetrics and Gynaecology, "Dr I. Cantacuzno" Hospital, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.
J Clin Med. 2025 Apr 8;14(8):2564. doi: 10.3390/jcm14082564.
: Prevalence of umbilical cord cysts is largely unknown, mainly due to small dimensions and to the fact that only placental and fetal insertion of the umbilical cord are usually assessed. Older studies report a total prevalence of about 3%, regardless of the size. To date, no correlation between the gestational age, the size of the cyst at the moment of diagnosis and pregnancy prognosis can be made. : We managed a case of a large umbilical cyst diagnosed in the first trimester. As our experience with this pathology was limited, we performed a systematic review in order to find out the optimal management. : We report a case of a large umbilical cord cyst that ended in fetal demise at 13 weeks in the absence of any chromosomal and structural anomalies. Our results differ from what was expected from our literature review. Sixteen papers were included in our analysis. According to the selected papers, single cysts are more frequent than multiple cysts (79% single cysts). The mean value of the maximum diameter of the cyst was 32 mm, and there was no difference in number considering the localization of the cyst. Considering the cases in which genetic testing was performed, there were 22.76% modified results. The most frequent genetic disorder was trisomy 18 (53.57% from the modified results). : Large umbilical cord cysts are correlated with uncertain prognosis. We made the conclusion that large umbilical cord cystic lesions might have an unfavorable prognosis. Although there are case series that have shown an unproblematic evolution of the pregnancy, large umbilical cysts could be associated with increased risk of fetal anomalies and intrauterine fetal death.
脐带囊肿的患病率很大程度上未知，主要是因为囊肿尺寸小，且通常仅评估胎盘和脐带的胎儿插入部位。早期研究报告称，无论囊肿大小，总体患病率约为3%。迄今为止，无法确定胎龄、诊断时囊肿大小与妊娠预后之间的相关性。：我们处理了一例在孕早期诊断出的大型脐带囊肿病例。由于我们对这种病理情况的经验有限，我们进行了系统综述以找出最佳处理方法。：我们报告了一例大型脐带囊肿病例，该病例在孕13周时胎儿死亡，且无任何染色体和结构异常。我们的结果与文献综述的预期不同。我们的分析纳入了16篇论文。根据所选论文，单个囊肿比多个囊肿更常见（单个囊肿占79%）。囊肿最大直径的平均值为32毫米，囊肿位置不同，其数量无差异。在进行基因检测的病例中，有22.76%的结果有改变。最常见的基因疾病是18三体（改变后的结果中占53.57%）。：大型脐带囊肿与预后不确定相关。我们得出结论，大型脐带囊性病变可能预后不良。尽管有病例系列显示妊娠过程无问题，但大型脐带囊肿可能与胎儿异常和宫内胎儿死亡风险增加有关。
