Perri Paolo, Curcio Federica, De Luca Michele, Piro Paolo, Trombino Sonia, Cassano Roberta
Department of Vascular and Endovascular Surgery, Annunziata Hospital, 1 Via Migliori, 87100 Cosenza, Italy.
Department of Pharmacy, Health and Nutritional Science, University of Calabria, Arcavacata, 87036 Rende, Italy.
Pharmaceuticals (Basel). 2025 Apr 16;18(4):584. doi: 10.3390/ph18040584.
The safe completion of a non-invasive procedure is crucial to the success of an endovascular approach. Chitosan, a natural polysaccharide derived from chitin, is an ideal material for the study and application of medical devices in post-operative wound management. The present work is based on a retrospective study conducted on a sample of patients treated with Axiostat (a sterile, single-use, non-absorbable dressing), composed of 100% chitosan and designed to instantly stop bleeding through a mucus adhesion mechanism for the treatment of conditions such as Leriche's syndrome. The objective was to evaluate the efficacy and safety of the hemostatic Axiostat dressing in patients undergoing anticoagulant and/or antiplatelet therapy in whom endovascular procedures using the axillary artery as an access site are performed to treat Leriche syndrome. The obtained results showed that Axiostat is safe and effective in promoting hemostasis at the axillary vascular access site even when prolonged hemostasis was required in patients on antiplatelet and anticoagulant therapy. The mean time to hemostasis was 5.75 min in all types of patients considered.
无创手术的安全完成对于血管内治疗方法的成功至关重要。壳聚糖是一种从几丁质衍生而来的天然多糖，是医疗器械在术后伤口管理中进行研究和应用的理想材料。本研究基于一项对使用Axiostat（一种无菌、一次性使用、不可吸收的敷料）治疗的患者样本进行的回顾性研究，该敷料由100%壳聚糖组成，旨在通过黏液粘附机制立即止血，用于治疗诸如勒里什综合征等病症。目的是评估止血性Axiostat敷料在接受抗凝和/或抗血小板治疗、以腋动脉作为穿刺部位进行血管内手术治疗勒里什综合征的患者中的疗效和安全性。所获结果表明，即使抗血小板和抗凝治疗的患者需要延长止血时间，Axiostat在促进腋血管穿刺部位止血方面也是安全有效的。在所有类型的患者中，平均止血时间为5.75分钟。
