Pinto-Leite Mariana, Martins Diana, Ferreira António Carlos, Silva Cláudia, Trindade Fábio, Saraiva Francisca, Vitorino Rui, Barros Raquel, Lima Pedro A, Leite-Moreira Adelino, Ferreira João Pedro, S Barros António, Miranda Isabel M
RISE-Health, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal.
iBiMED, Department of Medical Sciences, University of Aveiro, 3810-193 Aveiro, Portugal.
Nutrients. 2025 Mar 7;17(6):943. doi: 10.3390/nu17060943.
: and Spirulina supplementation may reduce the risk of cardiometabolic diseases by better controlling blood cholesterol, triglycerides, glucose, weight, and blood pressure (BP). However, the available studies are limited in size and have used different outcomes. : To gain power in assessing the impact of microalgae supplements on cardiovascular risk factors, we searched PubMed on 3 February 2023 for randomised controlled trials assessing the effects of and Spirulina on modifiable cardiovascular risk factors. : We found 12 studies in and 9 studies on Spirulina. Depending on the available outcomes, varying numbers of participants (: 168 to 279; Spirulina: 101 to 299) were included. Our analysis showed that supplementation had a neutral effect on BP and lipemia. On the other hand, Spirulina intake led to a significant reduction in diastolic BP (-0.42, 95% CI: -0.81 to -0.02, = 0.04) but did not significantly affect lipemia indexes, despite a trend toward a reduction in total cholesterol (-0.17, 95% CI: -0.39 to 0.06, = 0.15). This meta-analysis suggests Spirulina supplementation can be used as an adjuvant to control cardiometabolic risk factors, particularly for BP. However, the magnitude of this effect is small and of uncertain clinical significance. : Further randomised trials are needed to better assess the potential of these supplements as adjuvants for the control of cardiovascular risk factors.
补充螺旋藻可能通过更好地控制血液中的胆固醇、甘油三酯、血糖、体重和血压（BP）来降低心血管代谢疾病的风险。然而，现有研究规模有限且使用了不同的结果指标。为了增强评估微藻补充剂对心血管危险因素影响的效力，我们于2023年2月3日在PubMed上搜索了评估补充剂和螺旋藻对可改变的心血管危险因素影响的随机对照试验。我们找到了12项关于补充剂的研究和9项关于螺旋藻的研究。根据可得的结果指标，纳入了不同数量的参与者（补充剂：168至279人；螺旋藻：101至299人）。我们的分析表明，补充剂对血压和血脂有中性作用。另一方面，摄入螺旋藻导致舒张压显著降低（-0.42，95%置信区间：-0.81至-0.02，P = 0.04），但尽管总胆固醇有降低趋势（-0.17，95%置信区间：-0.39至0.06，P = 0.15），螺旋藻对血脂指标没有显著影响。这项荟萃分析表明，补充螺旋藻可作为控制心血管代谢危险因素的辅助手段，尤其是对血压。然而，这种效果的程度较小且临床意义不确定。需要进一步的随机试验来更好地评估这些补充剂作为控制心血管危险因素辅助手段的潜力。
