Konola Ville-Markus, Multanen Juhani, Ihalainen Johanna K, Hintikka Jukka E, Jämsä Timo, Kautiainen Hannu, Nieminen Miika T, Pekkala Satu, Valtonen Maarit, Heinonen Ari
Faculty of Sport and Health Sciences, University of Jyväskylä, P.O. Box 35, Jyväskylä, FI, 40014, Finland.
South-Eastern Finland University of Applied Sciences, Savonlinna, Finland.
Osteoarthr Cartil Open. 2025 Apr 11;7(2):100609. doi: 10.1016/j.ocarto.2025.100609. eCollection 2025 Jun.
This study investigated the effects of a high-impact exercise regimen compared with a reference group on systemic cytokine levels in patients with mild knee osteoarthritis (OA). Furthermore, associations between cytokines and magnetic resonance imaging (MRI) transverse relaxation time (T2) mapping and metabolic equivalent task hours (MET-hours) during leisure-time physical activity (LTPA) were assessed.
In this secondary analysis, 73 postmenopausal women aged 50-65 years with mild knee OA were randomized to a 12-month high-impact aerobic/step aerobics training group (n = 35) or a non-training reference group (n = 38). The serum cytokine levels, including interleukin-1 alpha (IL-1α), IL-2, IL-4, IL-5, IL-6, IL-10, IL-13, IL-17, interferon-gamma (IFN-γ), and tumor necrosis factor alpha (TNF-α), were determined via multiplex cytokine assays. The cartilage structure of the medial tibial condyle was assessed by MRI T2 mapping. The primary outcome was between-group differences in cytokine level changes.
After a 12-month follow-up, no significant differences in cytokine level changes were found between the groups. In the intervention group, 12-month changes in TNF-α levels were associated with changes in medial tibial condyle T2. In the reference group, 12-month changes in IL-10 levels were associated with changes in medial tibial condyle T2 and the number of weekly LTPA MET-hours.
A progressive high-impact exercise regimen did not affect systemic cytokine levels compared to the reference group and could therefore offer a possible mode of exercise for postmenopausal women with mild knee OA.
ISRCTN58314639.
本研究调查了高强度运动方案与参照组相比，对轻度膝关节骨关节炎（OA）患者全身细胞因子水平的影响。此外，还评估了细胞因子与磁共振成像（MRI）横向弛豫时间（T2）映射以及休闲时间体力活动（LTPA）期间代谢当量任务小时数（MET-小时数）之间的关联。
在这项二次分析中，73名年龄在50 - 65岁的绝经后轻度膝关节OA女性被随机分为12个月的高强度有氧/踏板有氧训练组（n = 35）或非训练参照组（n = 38）。通过多重细胞因子检测法测定血清细胞因子水平，包括白细胞介素-1α（IL-1α）、IL-2、IL-4、IL-5、IL-6、IL-10、IL-13、IL-17、干扰素-γ（IFN-γ）和肿瘤坏死因子-α（TNF-α）。通过MRI T2映射评估内侧胫骨髁的软骨结构。主要结局是组间细胞因子水平变化的差异。
经过12个月的随访，两组之间细胞因子水平变化无显著差异。在干预组中，TNF-α水平的12个月变化与内侧胫骨髁T2的变化相关。在参照组中，IL-10水平的12个月变化与内侧胫骨髁T2的变化以及每周LTPA的MET-小时数相关。
与参照组相比，渐进性高强度运动方案并未影响全身细胞因子水平，因此可为轻度膝关节OA的绝经后女性提供一种可能的运动方式。
ISRCTN58314639。
