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综合性多组分干预措施,以支持整个人的健康老龄化。

Integrated multicomponent interventions to support healthy aging of the whole person.

机构信息

National Center for Complementary and Integrative Health (NCCIH), National Institutes of Health, Bethesda, Maryland, USA.

出版信息

Aging Cell. 2024 Jan;23(1):e14001. doi: 10.1111/acel.14001. Epub 2023 Oct 15.

DOI:10.1111/acel.14001
PMID:37840416
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10776112/
Abstract

Healthy aging is an integrated "whole person" process that involves an individual's biology, behavior, and social/physical environment. With the recent development of antiaging drugs, careful consideration of the respective roles of pharmacologic and nonpharmacologic approaches to both health and aging is in order. Recent advances in understanding the cellular and molecular mechanisms of aging are providing new measures that can be used as clinical outcomes in studying the impact of antiaging interventions in humans. This paper outlines the strategic interest of the National Center for Complementary and Integrative Health (NCCIH) in supporting the development, testing, and implementation of effective, scalable, and integrated multicomponent interventions to support healthy aging of the whole person.

摘要

健康老龄化是一个综合的“全人”过程,涉及个体的生物学、行为和社会/物理环境。随着抗衰老药物的最新发展,需要仔细考虑药物和非药物方法在健康和衰老方面的各自作用。最近在理解衰老的细胞和分子机制方面的进展为研究抗衰老干预措施对人类的影响提供了新的临床评估指标。本文概述了国家补充与综合健康中心(NCCIH)在支持有效、可扩展和综合的多组分干预措施的开发、测试和实施方面的战略利益,以支持整个人的健康老龄化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4594/10776112/0dfcfc4a50ba/ACEL-23-e14001-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4594/10776112/0dfcfc4a50ba/ACEL-23-e14001-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4594/10776112/0dfcfc4a50ba/ACEL-23-e14001-g002.jpg

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2
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Age Ageing. 2023 Feb 1;52(2). doi: 10.1093/ageing/afac328.
3
Multiple secondary outcome analyses: precise interpretation is important.多项次要结局分析:精确解读很重要。
Physiol Rev. 2025 Jul 1;105(3):1609-1694. doi: 10.1152/physrev.00045.2024. Epub 2025 Mar 20.
4
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Glob Adv Integr Med Health. 2024 Oct 18;13:27536130241293642. doi: 10.1177/27536130241293642. eCollection 2024 Jan-Dec.
5
Machine learning methods to discover hidden patterns in well-being and resilience for healthy aging.用于发现健康老龄化中幸福感和恢复力隐藏模式的机器学习方法。
J Nurs Scholarsh. 2025 Jan;57(1):72-81. doi: 10.1111/jnu.13025. Epub 2024 Sep 9.
6
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Antioxidants (Basel). 2024 Jun 12;13(6):715. doi: 10.3390/antiox13060715.
7
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8
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