Guo Shuang, Yang Fen, Zhang Jiyu, Liao Yuhan, Xia Ni, Tang Tingting, Wang Chaolong, Wang Qing K, Chen Chen, Hu Desheng, Shan Zhilei, Cheng Xiang
Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, China.
Hubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, China.
Biomedicines. 2025 Apr 9;13(4):920. doi: 10.3390/biomedicines13040920.
: Previous studies have shown varying efficacy of high-fiber diets containing different ingredients in abdominal aortic aneurysms (AAAs). This study aimed to identify which high-fiber diet protects against AAA in mice and elucidate the underlying mechanisms. : This study compared inulin, cellulose, and chow diets in terms of their impact on aneurysm enlargement, elastin degradation, matrix metalloproteinase 2 and 9 expressions, CD3+ T cell and CD68+ macrophage infiltration, and macrophage differentiation. It also examined gut microbiota composition, focusing on Akkermansia, and evaluated intestinal barrier function and systemic inflammatory response. : The inulin diet, but not the cellulose diet, compared with the chow diet, reduced aneurysm enlargement, elastin degradation, matrix metalloproteinase 2 and 9 expressions, CD3+ T cell and CD68+ macrophage infiltration, and skewed macrophage towards M2 differentiation. The inulin diet enriched Akkermansia in both the small and large intestine. The inulin diet also enhanced the intestinal barrier by augmenting goblet cells, upregulating the gene related to the epithelial barrier and antibacterial peptides in the small intestine, and reducing circulating lipopolysaccharide and interleukin-1β levels. The inulin diet lowered the proportion of Ly6Chi monocytes and C-C chemokine receptor 2 expression on these cells in the bone marrow, reducing aneurysm infiltration. Administering Akkermansia to AAA mice decreased intestinal permeability and mitigated AAA. : A diet rich in fermentable fiber inulin, as opposed to cellulose, alleviates AAA in mice. This beneficial effect is attributed to the enhanced presence of Akkermansia bacteria and improvement of the intestinal barrier.
先前的研究表明，含有不同成分的高纤维饮食对腹主动脉瘤（AAA）的疗效各异。本研究旨在确定哪种高纤维饮食可预防小鼠的AAA，并阐明其潜在机制。：本研究比较了菊粉、纤维素和普通饮食对动脉瘤扩大、弹性蛋白降解、基质金属蛋白酶2和9表达、CD3 + T细胞和CD68 +巨噬细胞浸润以及巨噬细胞分化的影响。它还检查了肠道微生物群组成，重点是阿克曼氏菌，并评估了肠道屏障功能和全身炎症反应。：与普通饮食相比，菊粉饮食而非纤维素饮食可减少动脉瘤扩大、弹性蛋白降解、基质金属蛋白酶2和9表达、CD3 + T细胞和CD68 +巨噬细胞浸润，并使巨噬细胞向M2分化倾斜。菊粉饮食使小肠和大肠中的阿克曼氏菌富集。菊粉饮食还通过增加杯状细胞、上调小肠中与上皮屏障和抗菌肽相关的基因以及降低循环脂多糖和白细胞介素-1β水平来增强肠道屏障。菊粉饮食降低了骨髓中Ly6Chi单核细胞的比例及其上C-C趋化因子受体2的表达，减少了动脉瘤浸润。给AAA小鼠施用阿克曼氏菌可降低肠道通透性并减轻AAA。：与纤维素相反，富含可发酵纤维菊粉的饮食可减轻小鼠的AAA。这种有益作用归因于阿克曼氏菌细菌的增加和肠道屏障的改善。
