N-单氟甲基化（硫代）氨基甲酸酯、甲酰胺、炔酰胺及相关衍生物的获取途径。
Access to N-Monofluoromethylated (Thio)Carbamates, Formamides, Alkynamides, and Related Derivatives.
作者信息
Zivkovic Filip G, Bahns Fritz, Hsu Che-Ming, Schoenebeck Franziska
机构信息
Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074, Aachen, Germany.
出版信息
Angew Chem Int Ed Engl. 2025 Jul 7;64(28):e202505478. doi: 10.1002/anie.202505478. Epub 2025 May 10.
Abstract
This work presents the first general synthetic access to N-CH₂F and N-CHRF carbamates, thiocarbamates, formamides, alkynamides, and related compounds. The synthetic approach employs N-CHF and N-CHRF carbamoyl fluorides as versatile strategic building blocks, which can be efficiently synthesized in a single step directly from readily available amines or imines.
摘要
这项工作展示了首次对N-CH₂F和N-CHRF氨基甲酸酯、硫代氨基甲酸酯、甲酰胺、炔酰胺及相关化合物进行通用合成的方法。该合成方法采用N-CHF和N-CHRF氨基甲酰氟作为通用的战略构建单元，它们可以直接从易得的胺或亚胺一步高效合成。
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