Liu Yichuan, Wen Zongquan, Zeng Nanrui
Digestive Endoscopy Center, Dongguan Kanghua Hospital, Dongguan, Guangdong, China.
Balkan Med J. 2025 May 5;42(3):233-241. doi: 10.4274/balkanmedj.galenos.2025.2025-1-87.
Both insufficient and excessive catch-up sleep durations have been implicated in influencing the risk of cardiovascular diseases (CVDs) and metabolic disorders. However, the specific impact of weekend catch-up sleep (WCS) on the relationship between hepatic steatosis (HS) and atherosclerotic cardiovascular disease (ASCVD) remains unclear.
This cross-sectional study aims to examine the potential regulatory effect of WCS on the association between controlled attenuation parameter (CAP) and ASCVD.
Weighted logistic regression analyses were employed to evaluate the associations of CAP and WCS with ASCVD, expressed in terms of odds ratios (ORs) and 95% confidence intervals (CIs). The study also explored the effect of WCS on the CAP-ASCVD relationship and assessed the potential regulatory role of WCS in subgroups based on age, gender, body mass index, and obesity status.
Eligible participants were categorized into two groups: those with an ASCVD risk < 7.5% (n = 1536) and those with an ASCVD risk ≥ 7.5% (n = 1612). After adjusting for covariates, CAP ≥ 274 dB/m was associated with a higher likelihood of ASCVD compared to the CAP < 274 dB/m (OR, 1.84, 95% CI, 1.24-2.73). When compared to a WCS duration of 0-1 hour, WCS ≥ 1 hour was found to increase the potential ASCVD risk associated with CAP (OR, 3.29, 95% CI, 1.41-7.68). Furthermore, among individuals with WCS ≥ 1 hour, CAP ≥ 274 dB/m was linked to a higher ASCVD risk than among those with CAP < 274 dB/m (OR, 3.72, 95% CI, 1.99-6.93). Additionally, in subgroups of participants aged ≥ 60 years, females, non-obese and obese individuals, WCS ≥ 1 hour was associated with an increased ASCVD risk related to CAP (all, < 0.05).
A WCS duration of ≥ 1 hour may be associated with an increased ASCVD risk in adults with HS aged ≥ 40 years. However, further research is necessary to clarify the causal relationships between WCS, HS, and ASCVD.
睡眠时间不足和过长均被认为会影响心血管疾病（CVD）和代谢紊乱的风险。然而，周末补觉（WCS）对肝脂肪变性（HS）与动脉粥样硬化性心血管疾病（ASCVD）之间关系的具体影响尚不清楚。
这项横断面研究旨在探讨WCS对受控衰减参数（CAP）与ASCVD之间关联的潜在调节作用。
采用加权逻辑回归分析来评估CAP和WCS与ASCVD的关联，以比值比（OR）和95%置信区间（CI）表示。该研究还探讨了WCS对CAP - ASCVD关系的影响，并根据年龄、性别、体重指数和肥胖状况评估了WCS在亚组中的潜在调节作用。
符合条件的参与者被分为两组：ASCVD风险<7.5%的参与者（n = 1536）和ASCVD风险≥7.5%的参与者（n = 1612）。在调整协变量后，与CAP < 274 dB/m相比，CAP≥274 dB/m与ASCVD发生可能性较高相关（OR，1.84，95% CI，1.24 - 2.73）。与WCS时长为0 - 1小时相比，发现WCS≥1小时会增加与CAP相关的潜在ASCVD风险（OR，3.29，95% CI，1.41 - 7.68）。此外，在WCS≥1小时的个体中，与CAP < 274 dB/m的个体相比，CAP≥274 dB/m与更高的ASCVD风险相关（OR，3.72，95% CI，1.99 - 6.93）。此外，在年龄≥60岁、女性、非肥胖和肥胖个体的亚组中，WCS≥1小时与与CAP相关的ASCVD风险增加相关（所有P < 0.05）。
WCS时长≥1小时可能与年龄≥40岁的HS成年患者ASCVD风险增加相关。然而，需要进一步研究以阐明WCS、HS和ASCVD之间的因果关系。
