Murata M, Ogawa E, Maki M
Jpn J Antibiot. 1985 Apr;38(4):915-20.
Cefpimizole (AC-1370) was administered to 5 cases with uterine myoma before hysterectomy, and tissue distribution was determined. AC-1370 was also administered to 5 cases with gynecological infections. The following results were obtained. One gram of AC-1370 was administered from 43 to 299 minutes before hysterectomy, tissue distribution of AC-1370, such as ovary, oviduct, myometrium, cervix uteri, and portio vaginalis was showed the highest level (30.0 approximately 49.5 micrograms/g) at 43 minutes after administration, and these were 39.0 approximately 64.4% of the concentration in uterine arterial blood. Tissue concentration of AC-1370 was then gradually decreased following with the decreasing of the concentration in uterine arterial blood. AC-1370 was administered to 3 cases with pyometra, 1 case with Bartholin abscess, 1 case with adnexitis. The clinical efficacy was good in all 5 cases. Bacteriological study revealed that A. faecalis and E. coli were eradicated, but B. fragilis was persisted. No side effect was observed in all cases.
在子宫切除术前，对5例子宫肌瘤患者给予头孢咪唑（AC - 1370），并测定其组织分布。还对5例妇科感染患者给予AC - 1370。获得了以下结果。在子宫切除术前43至299分钟给予1克AC - 1370，给药后43分钟时，AC - 1370在卵巢、输卵管、子宫肌层、子宫颈和阴道部等组织中的分布显示出最高水平（30.0至约49.5微克/克），这些组织中的浓度是子宫动脉血中浓度的39.0至约64.4%。随后，随着子宫动脉血中浓度的降低，AC - 1370的组织浓度逐渐下降。对3例积脓患者、1例巴氏腺脓肿患者和1例附件炎患者给予AC - 1370。所有5例患者的临床疗效均良好。细菌学研究表明，粪肠球菌和大肠杆菌被根除，但脆弱拟杆菌仍持续存在。所有病例均未观察到副作用。
