Obata I, Hayashi F, Imagawa N, Ochiai K, Koike K, Morimoto O, Hachiya S
Jpn J Antibiot. 1985 Apr;38(4):940-53.
Cefpimizole (AC-1370) was studied for its transference into adnexa uteri and uterine tissues as well as for its effects and safety on gynecological infections. The results obtained are as follows: Peak levels of AC-1370 were obtained in the antecubital vein and uterine artery at 10 minutes, in the tissues of adnexa uteri and uteri about 30 minutes after one shot intravenous injection of AC-1370 1 g, and relatively high concentrations were maintained for several hours. In the treatment of 30 cases of gynecological infections, the clinical efficacy of AC-1370 was assessed as effective in all cases. As for the bacteriological effects of AC-1370, 77.6% of isolated organisms were eradicated and 90% of all cases were effective. Side effects and abnormal laboratory findings due to AC-1370 were not observed during and after administration.
对头孢咪唑（AC - 1370）进行了研究，观察其向子宫附件和子宫组织中的转移情况，以及其对妇科感染的疗效和安全性。所得结果如下：静脉注射1g AC - 1370后，在前臂静脉和子宫动脉中，10分钟时达到AC - 1370的峰值水平；在子宫附件和子宫组织中，约30分钟时达到峰值水平，且较高浓度维持数小时。在治疗30例妇科感染病例中，评估AC - 1370的临床疗效为全部有效。至于AC - 1370的细菌学作用，77.6%的分离菌株被根除，所有病例中有90%有效。给药期间及给药后未观察到因AC - 1370引起的副作用及实验室检查异常。
