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冷大气压等离子体对小鼠模型伤口感染影响的评估。

Evaluation of cold atmospheric pressure plasma effects on wound infection in a mouse model.

作者信息

Shekari Reyhaneh, Zarrinsi Gholamreza, Siahpoush Vahid, Hesari Farzam Sheikhzadeh

机构信息

Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.

Research Institute for Applied Physics and Astronomy, University of Tabriz, Tabriz, Iran.

出版信息

Iran J Microbiol. 2025 Feb;17(1):59-68. doi: 10.18502/ijm.v17i1.17802.

DOI:10.18502/ijm.v17i1.17802
PMID:40330068
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12049748/
Abstract

BACKGROUND AND OBJECTIVES

Antibiotic resistance in microorganisms is a significant global health concern. Cold atmospheric plasma is an innovative and promising method for inactivating bacteria. This study aimed to evaluate the effects of cold plasma on in a mouse wound infection model.

MATERIALS AND METHODS

The disk diffusion method was used to perform antibiograms after isolating the bacteria. A multidrug-resistant strain was then selected. The bactericidal activity of cold helium plasma was investigated in vitro. The optimal cold plasma conditions were determined in the laboratory, with a flow of 3 liters per minute and a power of 1.1 watts. These conditions were later used for in vivo evaluations.

RESULTS

In a laboratory study, helium gas plasma treatment for 8 minutes reduced by 2.5 logs. In the in vivo study, plasma reduced the wound's microbial load in mice by 1.9 log. The antibiotic treatment group had a 1.2 log reduction. Both plasma and antibiotic therapies had similar effects on microbial inactivation.

CONCLUSION

The overall evaluation of wound healing time and pathological features showed that plasma was generally better than antibiotic treatment. Plasma can inactivate in wounds and accelerate wound healing.

摘要

背景与目的

微生物的抗生素耐药性是全球重大的健康问题。冷大气等离子体是一种用于灭活细菌的创新且有前景的方法。本研究旨在评估冷等离子体在小鼠伤口感染模型中的作用效果。

材料与方法

分离细菌后，采用纸片扩散法进行药敏试验。然后选择一株多重耐药菌株。在体外研究冷氦等离子体的杀菌活性。在实验室确定了冷等离子体的最佳条件，即每分钟3升的流速和1.1瓦的功率。这些条件随后用于体内评估。

结果

在实验室研究中，氦气等离子体处理8分钟使细菌数量减少了2.5个对数级。在体内研究中，等离子体使小鼠伤口的微生物负荷减少了1.9个对数级。抗生素治疗组减少了1.2个对数级。等离子体和抗生素疗法对微生物灭活的效果相似。

结论

对伤口愈合时间和病理特征的总体评估表明，等离子体总体上优于抗生素治疗。等离子体可使伤口内的细菌失活并加速伤口愈合。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf34/12049748/4bc88cb9f80e/IJM-17-59-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf34/12049748/4e5415dc4789/IJM-17-59-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf34/12049748/f60cab5a949f/IJM-17-59-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf34/12049748/093878176932/IJM-17-59-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf34/12049748/3f1835710c64/IJM-17-59-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf34/12049748/82fc7ee0c1aa/IJM-17-59-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf34/12049748/6a1a8a1082e3/IJM-17-59-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf34/12049748/d3074dbab8a5/IJM-17-59-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf34/12049748/4bc88cb9f80e/IJM-17-59-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf34/12049748/4e5415dc4789/IJM-17-59-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf34/12049748/f60cab5a949f/IJM-17-59-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf34/12049748/093878176932/IJM-17-59-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf34/12049748/3f1835710c64/IJM-17-59-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf34/12049748/82fc7ee0c1aa/IJM-17-59-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf34/12049748/6a1a8a1082e3/IJM-17-59-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf34/12049748/d3074dbab8a5/IJM-17-59-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf34/12049748/4bc88cb9f80e/IJM-17-59-g008.jpg

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High Burden of Antimicrobial Resistance among Bacteria Causing Pyogenic Wound Infections at a Tertiary Care Hospital in Kathmandu, Nepal.
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