• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Moving towards sequencing-based metabolomics.迈向基于测序的代谢组学。
Trends Genet. 2025 Jul;41(7):554-555. doi: 10.1016/j.tig.2025.04.006. Epub 2025 May 6.
2
UHPLC-QTOF-MS-based metabolomics joint high-throughput RNA sequencing transcriptomics approach for the analysis of fecal and liver biological samples and application in a case study for the mechanism of Qing-Kai-Ling oral liquid in treating MASLD.基于超高效液相色谱-四极杆飞行时间质谱的代谢组学联合高通量RNA测序转录组学方法用于分析粪便和肝脏生物样本，并应用于清开灵口服液治疗非酒精性脂肪性肝病的机制案例研究。
Anal Bioanal Chem. 2025 May 1. doi: 10.1007/s00216-025-05892-2.
3
Can a Liquid Biopsy Detect Circulating Tumor DNA With Low-passage Whole-genome Sequencing in Patients With a Sarcoma? A Pilot Evaluation.液体活检能否通过低深度全基因组测序检测肉瘤患者的循环肿瘤DNA？一项初步评估。
Clin Orthop Relat Res. 2025 Jan 1;483(1):39-48. doi: 10.1097/CORR.0000000000003161. Epub 2024 Jun 21.
4
Description of metabolic differences between castrated males and intact gilts obtained from high-throughput metabolomics of porcine plasma.通过猪血浆的高通量代谢组学获得的去势公猪和未阉割后备母猪之间代谢差异的描述。
J Anim Sci. 2025 Jan 4;103. doi: 10.1093/jas/skaf178.
5
One-carbon metabolites supplementation and nutrient restriction alter the fetal liver metabolomic profile during early gestation in beef heifers.补充一碳代谢物和营养限制会改变肉牛胎儿肝脏在早期妊娠的代谢组学特征。
J Anim Sci. 2024 Jan 3;102. doi: 10.1093/jas/skae258.
6
Optimizing fungal DNA extraction and purification for Oxford Nanopore untargeted shotgun metagenomic sequencing from simulated hemoculture specimens.优化从模拟血液培养标本中进行牛津纳米孔非靶向鸟枪法宏基因组测序的真菌DNA提取和纯化方法。
mSystems. 2025 Jun 17;10(6):e0116624. doi: 10.1128/msystems.01166-24. Epub 2025 Apr 8.
7
Comparison of cellulose, modified cellulose and synthetic membranes in the haemodialysis of patients with end-stage renal disease.纤维素、改性纤维素和合成膜在终末期肾病患者血液透析中的比较。
Cochrane Database Syst Rev. 2001(3):CD003234. doi: 10.1002/14651858.CD003234.
8
Plasma metabolites associated with endometriosis in adolescents and young adults.青少年和年轻成年人中与子宫内膜异位症相关的血浆代谢物。
Hum Reprod. 2025 May 1;40(5):843-854. doi: 10.1093/humrep/deaf040.
9
A New Measure of Quantified Social Health Is Associated With Levels of Discomfort, Capability, and Mental and General Health Among Patients Seeking Musculoskeletal Specialty Care.一种新的量化社会健康指标与寻求肌肉骨骼专科护理的患者的不适程度、能力以及心理和总体健康水平相关。
Clin Orthop Relat Res. 2025 Apr 1;483(4):647-663. doi: 10.1097/CORR.0000000000003394. Epub 2025 Feb 5.
10
High-Throughput Multiplexed Quantification of Molecules by Aptamer Sequencing (Apt-seq) in Single Cells.通过单细胞适配体测序（Apt-seq）对分子进行高通量多重定量
J Am Chem Soc. 2025 Jun 18;147(24):20394-20405. doi: 10.1021/jacs.5c01296. Epub 2025 Jun 9.

本文引用的文献

1
Quantifying metabolites using structure-switching aptamers coupled to DNA sequencing.使用与DNA测序相结合的结构转换适体对代谢物进行定量分析。
Nat Biotechnol. 2025 Feb 4. doi: 10.1038/s41587-025-02554-7.
2
Deep generative design of RNA aptamers using structural predictions.使用结构预测进行 RNA 适体的深度生成设计。
Nat Comput Sci. 2024 Nov;4(11):829-839. doi: 10.1038/s43588-024-00720-6. Epub 2024 Nov 6.
3
Machine learning guided aptamer refinement and discovery.机器学习指导的适体优化与发现。
Nat Commun. 2021 Apr 22;12(1):2366. doi: 10.1038/s41467-021-22555-9.
4
HMDB 4.0: the human metabolome database for 2018.HMDB 4.0：2018 年人类代谢组数据库。
Nucleic Acids Res. 2018 Jan 4;46(D1):D608-D617. doi: 10.1093/nar/gkx1089.
5
Challenges and opportunities for small molecule aptamer development.小分子适配体开发面临的挑战与机遇。
J Nucleic Acids. 2012;2012:748913. doi: 10.1155/2012/748913. Epub 2012 Oct 24.
6
From SOMAmer-based biomarker discovery to diagnostic and clinical applications: a SOMAmer-based, streamlined multiplex proteomic assay.从 SOMAmer 生物标志物发现到诊断和临床应用：基于 SOMAmer 的简化多重蛋白质组分析。
PLoS One. 2011;6(10):e26332. doi: 10.1371/journal.pone.0026332. Epub 2011 Oct 17.
7
Aptamer-based multiplexed proteomic technology for biomarker discovery.基于适配体的多重蛋白质组学技术用于生物标志物发现。
PLoS One. 2010 Dec 7;5(12):e15004. doi: 10.1371/journal.pone.0015004.
8
High-resolution cross-reactive array for alkaloids.
Chem Commun (Camb). 2009 Jun 14(22):3193-5. doi: 10.1039/b900001a. Epub 2009 May 1.
9
Label-free electronic detection of thrombin in blood serum by using an aptamer-based sensor.使用基于适配体的传感器对血清中的凝血酶进行无标记电子检测。
Angew Chem Int Ed Engl. 2005 Aug 26;44(34):5456-9. doi: 10.1002/anie.200500989.
10
Structure-switching signaling aptamers.结构转换信号适配体
J Am Chem Soc. 2003 Apr 23;125(16):4771-8. doi: 10.1021/ja028962o.

迈向基于测序的代谢组学。

Moving towards sequencing-based metabolomics.

作者信息

Clark-ElSayed Alia, Ellington Andrew D, Marcotte Edward M

机构信息

Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.

Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.

出版信息

Trends Genet. 2025 Jul;41(7):554-555. doi: 10.1016/j.tig.2025.04.006. Epub 2025 May 6.

DOI:10.1016/j.tig.2025.04.006
PMID:40335328
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12237595/
Abstract

Metabolites are chemically heterogeneous and difficult to quantify in easily read formats. Recently, Tan and Fraser demonstrated that metabolites can be readily quantified by pairing aptamer function with DNA sequencing. This reflects a larger trend of sequencing for assessing biomolecule abundances, further leading to sequencing being a universal analytical tool.

摘要

代谢物在化学性质上具有异质性，并且难以以易于读取的格式进行定量。最近，Tan和Fraser证明，通过将适体功能与DNA测序相结合，可以轻松地对代谢物进行定量。这反映了用于评估生物分子丰度的测序的更大趋势，进一步使测序成为一种通用的分析工具。