迈向基于测序的代谢组学。
Moving towards sequencing-based metabolomics.
作者信息
Clark-ElSayed Alia, Ellington Andrew D, Marcotte Edward M
机构信息
Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
出版信息
Trends Genet. 2025 Jul;41(7):554-555. doi: 10.1016/j.tig.2025.04.006. Epub 2025 May 6.
Abstract
Metabolites are chemically heterogeneous and difficult to quantify in easily read formats. Recently, Tan and Fraser demonstrated that metabolites can be readily quantified by pairing aptamer function with DNA sequencing. This reflects a larger trend of sequencing for assessing biomolecule abundances, further leading to sequencing being a universal analytical tool.
摘要
代谢物在化学性质上具有异质性，并且难以以易于读取的格式进行定量。最近，Tan和Fraser证明，通过将适体功能与DNA测序相结合，可以轻松地对代谢物进行定量。这反映了用于评估生物分子丰度的测序的更大趋势，进一步使测序成为一种通用的分析工具。
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