Siddiqi Imran, Rahman Raphia, Brazdzionis James, Savla Paras, Hough Jordan M, Agrawal Devendra K, Connett David, Miulli Dan E
Neurosurgery, Riverside University Health System Medical Center, Moreno Valley, USA.
Internal Medicine-Pediatrics, Loma Linda University Medical Center, Loma Linda, USA.
Cureus. 2025 Apr 10;17(4):e82032. doi: 10.7759/cureus.82032. eCollection 2025 Apr.
Recent technological advancements have led to the development of portable helmet systems equipped with induction sensor stimulators for non-invasively monitoring neural electromagnetic fields in real-time. The helmet incorporates a Mu-metal shield, a material designed to block low-frequency electromagnetic fields and to reduce external interference. This study utilized an adult pig model to validate the ability of these sensors to record and stimulate neural activity through pig skulls, which closely mimic human cranial anatomy. Sensor-stimulators, which both detect and deliver electromagnetic stimulation, were integrated into the helmet for neural activity monitoring. Employing proprietary BS-1000 induction sensor stimulators integrated into a custom-designed helmet, our research focused on the efficacy of transmitting and modulating electromagnetic fields (EMFs) beyond the varied thicknesses of the pig skull. Induction sensors, a type of electromagnetic field sensor, were used to measure neural signals non-invasively. The experimental setup included measuring EMF responses at baseline and under conditions of incremental cranial barrier thicknesses, assessing both the recording and stimulating capabilities of the system. Results indicated that the EMF penetrated the swine skull and that the sensors maintained signal integrity and functionality despite increases in bone thickness of the pig skull compared to humans, successfully capturing and stimulating neural activity across all tested scenarios. These findings demonstrate the potential of this technology for non-invasive neuromodulation and neural monitoring. Its application in traumatic brain injury (TBI) research could facilitate real-time assessment of neural function and aid in the development of targeted therapeutic interventions.
最近的技术进步促使了配备感应传感器刺激器的便携式头盔系统的发展,用于实时非侵入性监测神经电磁场。该头盔包含一个坡莫合金屏蔽层,这种材料旨在阻挡低频电磁场并减少外部干扰。本研究利用成年猪模型来验证这些传感器通过猪颅骨记录和刺激神经活动的能力,猪颅骨与人类颅骨解剖结构非常相似。将既能检测又能传递电磁刺激的传感器刺激器集成到头盔中用于神经活动监测。我们的研究采用集成在定制设计头盔中的专利BS - 1000感应传感器刺激器,重点关注在猪颅骨不同厚度情况下传输和调制电磁场(EMF)的效果。感应传感器作为一种电磁场传感器,用于非侵入性测量神经信号。实验设置包括在基线以及颅骨屏障厚度增加的条件下测量EMF反应,评估系统的记录和刺激能力。结果表明,尽管与人类相比猪颅骨的骨厚度增加,但EMF仍能穿透猪颅骨,并且传感器在所有测试场景中都保持了信号完整性和功能,成功捕获并刺激了神经活动。这些发现证明了该技术在非侵入性神经调节和神经监测方面的潜力。其在创伤性脑损伤(TBI)研究中的应用有助于实时评估神经功能,并有助于开发针对性的治疗干预措施。