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广藿香乙醇提取物对阿霉素诱导的3T3-L1成纤维细胞系衰老特征的影响

Patchouli Ethanol Extract Benth. Against Aging Profiles in Doxorubicin-Induced 3T3-L1 Fibroblast Cell Lines.

作者信息

Santoso Teguh, Khairani Astrid Feinisa, Bashari Muhammad Hasan, Ramadhanti Julia, Rohmawati Enny, Oktora Monika Pury, Wiraswati Hesti Lina

机构信息

Graduate School of Master Program in Anti-Aging and Aesthetic Medicine Faculty of Medicine, Universitas Padjadjaran Bandung West Java Indonesia.

Department of Biomedical Sciences Faculty of Medicine, Universitas Padjadjaran Bandung West Java Indonesia.

出版信息

Aging Med (Milton). 2025 Apr 18;8(2):156-163. doi: 10.1002/agm2.70014. eCollection 2025 Apr.

DOI:10.1002/agm2.70014
PMID:40353056
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12064996/
Abstract

OBJECTIVES

This research aimed to investigate the potential of Benth's ethanolic extract (PCEE) as an antiaging agent.

METHODS

We treated 3T3-L1 cells induced by doxorubicin with PCEE and assessed them with antiaging markers such as gene and telomere length with polymerase chain reaction (PCR), or reactive oxygen species (ROS) accumulation with 2,7-dichlorofluorescein diacetate (DCFHDA).

RESULTS

This study demonstrates that PCEE can inhibit ROS accumulation, decrease the expression level of the senescence-associated β-galactosidase (SA-β-gal) and maintain telomere length in doxorubicin-induced 3T3-L1 cells.

CONCLUSION

These studies reveal that PCEE is a promising antiaging agent. An in vivo approach should be conducted for further research.

摘要

目的

本研究旨在探讨本氏乙醇提取物（PCEE）作为一种抗衰老剂的潜力。

方法

我们用PCEE处理阿霉素诱导的3T3-L1细胞，并用聚合酶链反应（PCR）检测基因和端粒长度等抗衰老标志物，或用二氯二氢荧光素二乙酸酯（DCFHDA）检测活性氧（ROS）积累来评估这些细胞。

结果

本研究表明，PCEE可以抑制阿霉素诱导的3T3-L1细胞中ROS的积累，降低衰老相关β-半乳糖苷酶（SA-β-gal）的表达水平，并维持端粒长度。

结论

这些研究表明PCEE是一种有前景的抗衰老剂。应采用体内实验方法进行进一步研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60df/12064996/2d2b660caab7/AGM2-8--g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60df/12064996/3423a1bedf48/AGM2-8--g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60df/12064996/faa90276869d/AGM2-8--g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60df/12064996/bccc05109daa/AGM2-8--g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60df/12064996/d62b87388317/AGM2-8--g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60df/12064996/82b515422391/AGM2-8--g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60df/12064996/2d2b660caab7/AGM2-8--g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60df/12064996/3423a1bedf48/AGM2-8--g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60df/12064996/faa90276869d/AGM2-8--g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60df/12064996/bccc05109daa/AGM2-8--g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60df/12064996/d62b87388317/AGM2-8--g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60df/12064996/82b515422391/AGM2-8--g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60df/12064996/2d2b660caab7/AGM2-8--g002.jpg

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Plants (Basel). 2023 Mar 1;12(5):1088. doi: 10.3390/plants12051088.
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Hallmarks of aging: An expanding universe.衰老的特征：一个不断扩大的领域。
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Natural Compounds and Products from an Anti-Aging Perspective.从抗衰老角度看天然化合物和产品。
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Study on the effect of Pogostemon cablin Benth on skin aging based on network pharmacology.基于网络药理学的广藿香对皮肤衰老影响的研究
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Patchouli Alcohol Inhibits D-Gal Induced Oxidative Stress and Ameliorates the Quality of Aging Cartilage via Activating the Nrf2/HO-1 Pathway in Mice.香豆素醇通过激活 Nrf2/HO-1 通路抑制 D-半乳糖诱导的氧化应激并改善衰老小鼠软骨的质量。
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