Casacuberta Josep, Barro Francisco, Braeuning Albert, de Maagd Ruud, Epstein Michelle M, Frenzel Thomas, Gallois Jean-Luc, Koning Frits, Messéan Antoine, Moreno F Javier, Nogué Fabien, Savoini Giovanni, Schulman Alan H, Tebbe Christoph, Veromann Eve, Ardizzone Michele, De Sanctis Giacomo, Dumont Antonio Fernandez, Ferrari Arianna, Gennaro Andrea, Gómez Ruiz José Ángel, Goumperis Tilemachos, Kagkli Dafni Maria, Lewandowska Aleksandra, Camargo Ana M, Franco Maria Neri, Piffanelli Pietro, Raffaello Tommaso, Rodrigues Marta, Sánchez-Brunete Elena
EFSA J. 2025 May 12;23(5):e9381. doi: 10.2903/j.efsa.2025.9381. eCollection 2025 May.
Genetically modified sugar beet KWS20-1 was developed to confer tolerance to glyphosate-, dicamba- and glufosinate-ammonium-based herbicides. These properties were achieved by introducing the , and expression cassettes. The molecular characterisation data and bioinformatic analyses do not identify issues requiring further safety assessment. None of the identified differences in the agronomic/phenotypic and compositional characteristics tested between sugar beet KWS20-1 and its conventional counterpart need further assessment, except for pectin in roots, which underwent additional evaluation and was found not to raise any safety or nutritional concerns. The GMO Panel does not identify safety concerns regarding the potential toxicity and allergenicity of the CP4 EPSPS, DMO and PAT proteins as expressed in sugar beet KWS20-1, and finds no evidence that the genetic modification would change the overall safety of sugar beet KWS20-1 as food and feed. In the context of this application, the consumption of food and feed from sugar beet KWS20-1 does not represent a nutritional concern in humans and animals. The GMO Panel concludes that sugar beet KWS20-1 is as safe as the conventional counterpart and non-GM sugar beet reference varieties tested, and no post-market monitoring of food/feed is considered necessary. The scope of the application does not include cultivation and import of viable materials in the EU and the products would be expected to only contain residual amounts of DNA and protein. The environmental risk assessment was limited to the possible plant-to-bacteria horizontal gene transfer and the evaluation of potential interactions of KWS20-1 sugar beet products with biogeochemical cycles, and neither of them indicates a safety concern. The GMO Panel concludes that the sugar beet KWS20-1 is as safe as its conventional counterpart and the tested non-GM reference sugar beet varieties with respect to potential effects on human and animal health and the environment.
转基因甜菜KWS20 - 1被培育出来以获得对草甘膦、麦草畏和草铵膦类除草剂的耐受性。这些特性是通过导入 、 和 表达盒实现的。分子特征数据和生物信息学分析未发现需要进一步安全评估的问题。除了根部果胶，在甜菜KWS20 - 1与其传统对照之间测试的农艺/表型和成分特征中所识别出的差异均无需进一步评估，根部果胶经过了额外评估，结果表明不存在任何安全或营养方面的问题。转基因生物小组未发现甜菜KWS20 - 1中表达的CP4 EPSPS、DMO和PAT蛋白的潜在毒性和致敏性存在安全问题，且没有证据表明基因改造会改变甜菜KWS20 - 1作为食品和饲料的整体安全性。在本申请的背景下，食用甜菜KWS20 - 1的食品和饲料对人和动物不构成营养方面的问题。转基因生物小组得出结论，甜菜KWS20 - 1与传统对照以及测试的非转基因甜菜参考品种一样安全，无需对食品/饲料进行上市后监测。本申请的范围不包括在欧盟种植和进口有活力的材料，预计产品仅含有残留量的DNA和蛋白质。环境风险评估仅限于可能的植物到细菌的水平基因转移以及KWS20 - 1甜菜产品与生物地球化学循环潜在相互作用的评估，两者均未表明存在安全问题。转基因生物小组得出结论，就对人类和动物健康以及环境的潜在影响而言，甜菜KWS20 - 1与其传统对照以及测试的非转基因参考甜菜品种一样安全。
