Casacuberta Josep, Barro Francisco, Braeuning Albert, Cubas Pilar, de Maagd Ruud, Epstein Michelle M, Frenzel Thomas, Gallois Jean-Luc, Koning Frits, Messéan Antoine, Moreno F Javier, Nogué Fabien, Savoini Giovanni, Schulman Alan H, Tebbe Christoph, Veromann Eve, Ardizzone Michele, De Sanctis Giacomo, Dumont Antonio Fernandez, Ferrari Arianna, Gennaro Andrea, Gómez Ruiz José Ángel, Goumperis Tilemachos, Grammatikou Paschalina, Kagkli Dafni Maria, Lenzi Paolo, Lewandowska Aleksandra, Camargo Ana M, Neri Franco Maria, Piffanelli Pietro, Raffaello Tommaso
EFSA J. 2025 Mar 19;23(3):e9282. doi: 10.2903/j.efsa.2025.9282. eCollection 2025 Mar.
Genetically modified maize DAS1131 was developed to confer resistance to certain susceptible lepidopteran pests, as well as tolerance to glyphosate herbicide, these properties were achieved by introducing the and expression cassettes. The molecular characterisation data and bioinformatic analyses do not identify issues requiring food/feed safety assessment. None of the identified differences in the agronomic/phenotypic and compositional characteristics tested between maize DAS1131 and its conventional counterpart needs further assessment, except for crude fat in grain which does not raise safety and nutritional concerns. The Panel on Genetically Modified Organisms (GMO Panel) does not identify safety concerns regarding the toxicity and allergenicity of the Cry1Da2 and DGT-28 EPSPS proteins as expressed in maize DAS1131 and finds no evidence that the genetic modification would change the overall allergenicity of maize DAS1131. In the context of this application, the consumption of food and feed from maize DAS1131 does not represent a nutritional concern in humans and animals. The GMO Panel concludes that maize DAS1131 is as safe as the conventional counterpart and the non-GM maize varieties tested, and no post-market monitoring of food/feed is considered necessary. In the case of release of maize DAS1131 into the environment, including viable grains, this would not raise environmental safety concerns. The post-market environmental monitoring plan and reporting intervals are in line with the intended uses of maize DAS1131. The GMO Panel concludes that maize DAS1131 is as safe as its conventional counterpart and the tested non-GM maize varieties with respect to potential effects on human and animal health and the environment.
转基因玉米DAS1131旨在获得对某些易感鳞翅目害虫的抗性以及对草甘膦除草剂的耐受性，这些特性通过导入 和 表达盒实现。分子特征数据和生物信息学分析未发现需要进行食品/饲料安全性评估的问题。除了籽粒中的粗脂肪不会引发安全性和营养方面的担忧外，玉米DAS1131与其传统对照品种在农艺学/表型和成分特征方面所检测到的差异均无需进一步评估。转基因生物小组（GMO小组）未发现玉米DAS1131中表达的Cry1Da2和DGT - 28 EPSPS蛋白的毒性和致敏性存在安全问题，也没有证据表明基因改造会改变玉米DAS1131的整体致敏性。在此申请的背景下，食用玉米DAS1131的食品和饲料对人类和动物不构成营养方面的担忧。GMO小组得出结论，玉米DAS1131与传统对照品种以及所测试的非转基因玉米品种一样安全，无需对食品/饲料进行上市后监测。如果将玉米DAS1131释放到环境中，包括有活力的籽粒，这不会引发环境安全问题。上市后环境监测计划和报告间隔符合玉米DAS1131的预期用途。GMO小组得出结论，就对人类和动物健康以及环境的潜在影响而言，玉米DAS1131与其传统对照品种以及所测试的非转基因玉米品种一样安全。
