Chen Ningning, Li Yunxia, Li Xiaoying
Department of Neonatology, Children's Hospital Affiliated to Shandong University (Jinan Children's Hospital), No. 23976, Jingshi Road, Jinan, 250022, Shandong, China.
School of Basic Medical Sciences, Shandong University, Jinan, China.
Clin Exp Med. 2025 May 14;25(1):160. doi: 10.1007/s10238-025-01678-z.
Liver disease (LD) is complex pathological condition that has emerged as a major threat to human health and the quality of life. Nonetheless, the molecular mechanisms underlying the pathogenesis of LD have not yet been fully elucidated. Recently, a large amount of evidence has shown that long noncoding RNAs (lncRNAs) play important roles in diverse biological processes in the liver. The dysregulation of lncRNAs in the liver, for example, can affect tumor proliferation, migration, and invasion, contribute to hepatic metabolism disorder of lipid and glucose, and shape of hepatic tumoral microenvironment. Thus, a comprehensive understanding of the functional roles of lncRNAs in LD pathogenesis may provide new perspectives for the development of novel diagnostic and therapeutic tools. In the present review, we summarize the current findings on the relationship between lncRNAs and LD, including the modes of action of lncRNAs, the biological significance of lncRNAs in the pathogenesis of LD, especially in hepatocellular carcinoma (HCC) as well as in some non-neoplastic disorders, and the potential use of lncRNAs as diagnostic biomarkers and therapeutic targets for LD.
肝脏疾病（LD）是一种复杂的病理状况，已成为对人类健康和生活质量的重大威胁。尽管如此，LD发病机制的分子机制尚未完全阐明。最近，大量证据表明，长链非编码RNA（lncRNAs）在肝脏的多种生物学过程中发挥重要作用。例如，肝脏中lncRNAs的失调可影响肿瘤增殖、迁移和侵袭，导致脂质和葡萄糖的肝脏代谢紊乱，并塑造肝脏肿瘤微环境。因此，全面了解lncRNAs在LD发病机制中的功能作用可能为新型诊断和治疗工具的开发提供新的视角。在本综述中，我们总结了关于lncRNAs与LD之间关系的当前研究结果，包括lncRNAs的作用模式、lncRNAs在LD发病机制中的生物学意义，特别是在肝细胞癌（HCC）以及一些非肿瘤性疾病中的意义，以及lncRNAs作为LD诊断生物标志物和治疗靶点的潜在用途。
