Valença Andreia, Fernandes Gonçalo, Smolders Joaquim, Patrício Rui, Belas Adriana
Faculty of Veterinary Medicine, Lusófona University - Lisbon University Centre, Lisbon, Portugal.
I-MVET-Research in Veterinary Medicine, Faculty of Veterinary Medicine, Lusófona University - Lisbon University Centre, Lisbon, Portugal.
Front Vet Sci. 2025 Apr 30;12:1579193. doi: 10.3389/fvets.2025.1579193. eCollection 2025.
Common leopard geckos () and central bearded dragon () are widely kept as pets but can harbor pathogenic bacteria, including antimicrobial-resistant (AMR) bacteria. This study aimed to research the frequency of β-lactamase-producing Enterobacterales in these two reptile species. A total of 132 samples were collected from the oral and cloacal cavities of healthy common leopard geckos and central bearded dragons in the Lisbon area, Portugal. Antimicrobial resistance was assessed for third-generation cephalosporin (3GC)-resistant Enterobacterales. The results revealed that 3GC-resistant Enterobacterales were observed in 17.9% ( = 14/78) of the reptiles. The most commonly identified species were: Citrobacter and . Furthermore, some isolates produced extended-spectrum β-lactamases (ESBLs) and AmpC β-lactamases (AmpC) encoding genes such as , and . These findings emphasize the potential role of these reptiles in the spread of AMR bacteria, particularly in urban settings where human- animal interactions are frequent. Given the zoonotic risks, this study emphasizes the importance of continued surveillance and responsible antimicrobial use in both veterinary and human medicine to mitigate the spread of AMR bacteria.
普通豹纹守宫（ ）和中部鬃狮蜥（ ）作为宠物被广泛饲养，但可能携带致病细菌，包括耐抗菌药物（AMR）细菌。本研究旨在调查这两种爬行动物中产β-内酰胺酶肠杆菌科细菌的频率。从葡萄牙里斯本地区健康的普通豹纹守宫和中部鬃狮蜥的口腔和泄殖腔共采集了132份样本。对耐第三代头孢菌素（3GC）的肠杆菌科细菌进行了抗菌药物耐药性评估。结果显示，17.9%（ = 14/78）的爬行动物中观察到耐3GC的肠杆菌科细菌。最常鉴定出的菌种为：柠檬酸杆菌 和 。此外，一些分离株产生了超广谱β-内酰胺酶（ESBLs）和AmpC β-内酰胺酶（AmpC）编码基因，如 、 和 。这些发现强调了这些爬行动物在AMR细菌传播中的潜在作用，特别是在人与动物互动频繁的城市环境中。鉴于人畜共患病风险，本研究强调了在兽医和人类医学中持续监测和合理使用抗菌药物以减轻AMR细菌传播的重要性。
