Department of Emergency Intensive Care Unit, Yangpu Hospital, School of Medicine, Tongji University, 450 Tengyue Road, Shanghai, China.
Genoxor Medical Science and Technology Inc., Shanghai, China.
BMC Infect Dis. 2022 Jul 15;22(1):616. doi: 10.1186/s12879-022-07583-0.
The early clinical diagnosis of spinal infections in elderly patients with recessive or atypical symptoms is difficult. Klebsiella aerogenes is a common opportunistic bacterium that can infect the respiratory tract, urinary tract, and even the central nervous system. However, whether it can infect the lumbar spine has not been previously described.
In this paper, we report the case of a 69-year-old female patient with osteoporosis who was initially diagnosed with hemolytic anemia. Later, she was diagnosed with K. aerogenes infection of the lumbar spine based on imaging combined with blood culture and metagenome next-generation sequencing (mNGS) detection. After precise medication, the lumbar degeneration was improved.
Bacterial infection should therefore be considered in cases of lumbar degenerative disease in middle-aged and elderly patients.
对于隐性或非典型症状的老年患者，早期临床诊断脊柱感染较为困难。产气克雷伯菌是一种常见的机会致病菌，可感染呼吸道、泌尿道，甚至中枢神经系统。但此前尚未有其感染腰椎的报道。
本文报告了一例 69 岁女性骨质疏松症患者，最初诊断为溶血性贫血。后来，根据影像学结合血培养和宏基因组下一代测序（mNGS）检测，诊断为产气克雷伯菌感染腰椎。经精准用药后，腰椎退行性病变得到改善。
对于中老年腰椎退行性疾病患者，应考虑细菌感染的可能性。
