头孢噻肟在患脑膜炎儿童脑脊液中的扩散。
Cefotaxime diffusion into cerebrospinal fluid of children with meningitis.
作者信息
Asmar B I, Thirumoorthi M C, Buckley J A, Kobos D M, Dajani A S
出版信息
Antimicrob Agents Chemother. 1985 Jul;28(1):138-40. doi: 10.1128/AAC.28.1.138.
Abstract
Cefotaxime diffused consistently and in therapeutic levels into the cerebrospinal fluid (CSF) of 13 children successfully treated for bacterial meningitis. CSF cefotaxime levels early (6.0 micrograms/ml) and late (1.2 micrograms/ml) in treatment were severalfold the MBCs for the infecting organisms. After a single 40-mg/kg dose to each of five infants with ventriculostomies, mean CSF levels of cefotaxime were 6.4, 5.7, and 4.5 micrograms/ml at 2, 4, and 6 h, respectively.
摘要
头孢噻肟持续且以治疗浓度扩散至13名成功治愈细菌性脑膜炎的儿童的脑脊液（CSF）中。治疗早期（6.0微克/毫升）和晚期（1.2微克/毫升）的脑脊液头孢噻肟水平是感染病原体最低杀菌浓度（MBC）的数倍。对五名行脑室造口术的婴儿各单次给予40毫克/千克剂量后，头孢噻肟的脑脊液平均水平在2、4和6小时时分别为6.4、5.7和4.5微克/毫升。
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