Houtman P M, Kallenberg C G, Wouda A A, The T H
Ann Rheum Dis. 1985 Sep;44(9):603-9. doi: 10.1136/ard.44.9.603.
Nailfold capillary patterns were studied in 107 patients with Raynaud's phenomenon (RP), including patients wih (n = 39) and without (n = 68) connective tissue disease (CTD). Capillary density was decreased in patients with sclerodactyly, digital ulcers, tuft resorption, and telangiectasia, compared with patients without these symptoms. In addition, an inverse relationship was found between the severity of RP at first presentation (as graded by photoelectric plethysmography during cooling) and the capillary density in patients with CTD (r = -0.45; p less than 0.05). In the total group of patients nailfold capillary density was inversely related to organ system involvement (r = -0.52; p less than 0.01). Decreased nailfold capillary density was observed, in particular, in patients with oesophageal hypomotility and in patients with chest x-rays compatible with interstitial fibrosis. As to factors supposedly involved in the pathogenesis of vascular changes in CTD, the presence of autoantibodies, increased levels of circulating immune complexes, and increased levels of acute phase reactants were all associated with a decreased number of nailfold capillaries. We conclude that loss of nailfold capillaries as observed by microscopy is a reflection of local and systemic vascular disease.
对107例雷诺现象（RP）患者的甲襞毛细血管形态进行了研究，其中包括合并（n = 39）和未合并（n = 68）结缔组织病（CTD）的患者。与无这些症状的患者相比，硬皮病样改变、指端溃疡、甲襞吸收和毛细血管扩张患者的毛细血管密度降低。此外，在初诊时RP的严重程度（通过冷却期间的光电体积描记法分级）与CTD患者的毛细血管密度之间发现呈负相关（r = -0.45；p < 0.05）。在全部患者组中，甲襞毛细血管密度与器官系统受累呈负相关（r = -0.52；p < 0.01）。尤其在食管动力低下患者和胸部X线表现符合间质性纤维化的患者中观察到甲襞毛细血管密度降低。关于推测参与CTD血管改变发病机制的因素，自身抗体的存在、循环免疫复合物水平升高和急性期反应物水平升高均与甲襞毛细血管数量减少有关。我们得出结论，显微镜下观察到的甲襞毛细血管丧失是局部和全身血管疾病的反映。
