Temur Nimet, Eren Esma Eryilmaz-, Celik Ilhami, Yıldız Ilknur E, Nisari Mustafa, Unal Ilay S, Celik Cagla, Ildiz Nilay, Ocsoy Ismail
Faculty of Pharmacy Department of Analytical Chemistry Erciyes University Kayseri Türkiye.
Kayseri City Training and Research Hospital University of Health Science Kayseri Türkiye.
Smart Med. 2025 Apr 25;4(2):e70007. doi: 10.1002/smmd.70007. eCollection 2025 Jun.
(MTB) remains a global health issue and continues to rank among the leading causes of death from infectious diseases worldwide. Its persistence is primarily attributed to the microorganism's challenging and time-consuming diagnosis and treatment, which drives the need for new diagnostic tests. The development of rapid, highly sensitive point-of-care (POC) tests is crucial, as these tests address the limitations of traditional methods, which are lengthy and exhibit low sensitivity. Early and rapid diagnostic tests ensure timely diagnoses and treatments for individuals while playing a pivotal role in preventing the spread of MTB and curbing societal transmission. These diagnostic tests significantly impact TB diagnosis and treatment, potentially breaking the chain of transmission and presenting a promising step toward combating the infection. Rapid and accurate diagnostic tests for MTB detection continue to attract significant attention in the literature and show promise for widespread application. However, they face challenges such as limited accessibility and usability, particularly in underdeveloped countries. The implementation of rapid tests requires careful consideration of time and resource efficiency compared with traditional tests. This study reviews the diagnostic tests developed for MTB detection, tracing their evolution from the past to the present.
结核分枝杆菌（MTB）仍然是一个全球健康问题，在全球范围内仍是传染病致死的主要原因之一。其持续存在主要归因于该微生物具有挑战性且耗时的诊断和治疗过程，这推动了对新型诊断测试的需求。开发快速、高灵敏度的即时检验（POC）测试至关重要，因为这些测试解决了传统方法的局限性，传统方法耗时冗长且灵敏度较低。早期和快速诊断测试可确保个体得到及时诊断和治疗，同时在预防MTB传播和控制社会传播方面发挥关键作用。这些诊断测试对结核病的诊断和治疗具有重大影响，有可能打破传播链，是对抗感染的一个有希望的举措。用于MTB检测的快速准确诊断测试在文献中持续受到高度关注，并显示出广泛应用的前景。然而，它们面临诸如可及性和可用性有限等挑战，尤其是在欠发达国家。与传统测试相比，快速测试的实施需要仔细考虑时间和资源效率。本研究回顾了为MTB检测开发的诊断测试，追溯其从过去到现在的演变。
