Leibowitz H M, Ryan W, Kupferman A, Vitale J J
Arch Ophthalmol. 1985 May;103(5):723-5. doi: 10.1001/archopht.1985.01050050115029.
New Zealand albino rabbits received daily intraperitoneal injections of alcohol (ethyl alcohol), 1.6 g/kg and the effect of short-term (three days) and long-term (six weeks) administration on corneal inflammation was studied. Both regimens produced an average peak serum concentration of more than 0.200 g/dL, a level consistent with gross intoxication in the majority of humans. Clinical signs of intoxication were present in all animals, manifested by a gross disturbance of equilibrium and gait. Neither regimen produced measurable liver damage. Nonetheless, following both regimens of alcohol administration, significantly fewer polymorphonuclear leukocytes invaded the corneas of animals receiving alcohol than invaded the corneas of simultaneously run controls receiving intraperitoneal saline. These data provide a mechanism to explain why an alcoholic individual might not cope with a corneal infection as well as a nonalcoholic person, an observation long thought to be true clinically.
新西兰白兔每天腹腔注射酒精（乙醇），剂量为1.6克/千克，研究了短期（三天）和长期（六周）给药对角膜炎症的影响。两种给药方案均使血清平均峰值浓度超过0.200克/分升，这一水平与大多数人严重中毒时的水平一致。所有动物均出现中毒的临床症状，表现为平衡和步态明显紊乱。两种给药方案均未造成可测量的肝损伤。然而，在两种酒精给药方案后，接受酒精的动物角膜中侵入的多形核白细胞明显少于同时腹腔注射生理盐水的对照动物角膜中侵入的多形核白细胞。这些数据提供了一种机制，用以解释酗酒者为何可能不如非酗酒者那样能应对角膜感染，这是临床上长期以来一直认为正确的一个观察结果。
