Chen Jia-Qi, Zhang Ling-Zhi, Ma Jie, Li Chuang-Jun, Zang Ying-Da, Sun Hua, Zhang Dong-Ming
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
J Asian Nat Prod Res. 2025 Jul;27(7):995-1004. doi: 10.1080/10286020.2025.2506527. Epub 2025 May 21.
Three new diterpenes, named pinusins D-F (-), were isolated from the Chinese medicine "" (the dried tuberculate or branched nodes of ), along with twelve known diterpenes. The structures of these new compounds were determined using detailed spectroscopic methods and ECD calculations. Compounds - displayed moderate hepatoprotective activity against HO-induced oxidative damage in HepG2 cells, while compounds - exhibited markedly enhanced efficacy -surpassing that of bicyclol (positive control).
从中药“”（的干燥瘤状或分枝节）中分离出三种新的二萜类化合物，命名为松脂素D - F（-），以及十二种已知的二萜类化合物。通过详细的光谱方法和ECD计算确定了这些新化合物的结构。化合物 - 对HepG2细胞中HO诱导的氧化损伤显示出适度的肝保护活性，而化合物 - 表现出明显增强的功效 - 超过双环醇（阳性对照）。
