Walz D
Food Chem Toxicol. 1985 Feb;23(2):299-302. doi: 10.1016/0278-6915(85)90032-8.
The irritant action of various buffer solutions was determined by the mouse skin test. All results for isosmolal solutions differing in initial pH values and buffer capacities could be satisfactorily represented by a general model which could be used to predict the irritancy of solutions with unphysiological pH values in contact with mucous membranes. The results obtained with hyperosmolal solutions are as yet too limited for such a general statement, but it appears that increasing osmolality gradually overrides the effect of the pH value. The relevance of the results to the prediction of irritant potentialities for man has been assessed by comparison with results of rabbit-eye tests carried out by Friedenwald et al. (Archs Ophthal., N.Y. 1944, 31, 279).
通过小鼠皮肤试验测定了各种缓冲溶液的刺激作用。初始pH值和缓冲容量不同的等渗溶液的所有结果都可以用一个通用模型令人满意地表示，该模型可用于预测与粘膜接触的非生理pH值溶液的刺激性。高渗溶液的结果目前还太有限，无法得出这样的一般性结论，但似乎渗透压的增加会逐渐掩盖pH值的影响。通过与Friedenwald等人（《纽约眼科学文献》，1944年，第31卷，第279页）进行的兔眼试验结果进行比较，评估了这些结果对预测人体刺激潜力的相关性。
