Gattoni Chiara, Bebe Katelin, Bross Rachelle, Wang Christina, Swerdloff Ronald S, Oudiz Ronald J, Kraus William E, Rossiter Harry B
The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, 90502.
Duke University School of Medicine, Durham, North Carolina.
Am J Cardiol. 2025 Sep 15;251:79-84. doi: 10.1016/j.amjcard.2025.05.021. Epub 2025 May 21.
Physical Activity Guidelines for Americans recommend at least 150 min/week of moderate (MPA) to vigorous (VPA) physical activity to maintain health, regardless of cardiovascular disease (CVD) risk. This study assessed whether physical activity (PA) intensity distinguishes between low and high CVD risk in 196 lean and obese Hispanic men aged 18-40 from the Study of Male Reproductive Epigenomics. PA was measured for 7 days using triaxial accelerometry. The 30-year "full" Framingham Risk Score (FRS) was calculated. Diet quality was assessed using the Healthy Eating Index (HEI-2020). Mean age was 30 ± 5 years with a median FRS of 14% (range: 3% to 85%). The high-risk group (n = 89) had a mean full FRS of 20.3% ± 11.1%, compared to 7.0% ± 3.6% in the low-risk group (n = 107; p <0.001). Both groups met guideline-recommended PA levels. However, the low-risk group performed more VPA (25 ± 20 vs 12 ± 12 min/day; p <0.001). Logistic regressions showed that each additional 1 min/day of VPA reduced the odds of high CVD risk by 4.4% (p = 0.007), adjusted for smoking, diet, age and Body Mass Index (BMI), while MPA did not significantly predict CVD risk (p = 0.823). Stepwise regressions showed that smoking status, BMI, VPA, and diet explained 47.8% of FRS variance (p <0.001), while MPA was excluded. In conclusion, VPA, but not MPA, significantly distinguished low from high CVD risk in young Hispanic men, highlighting the potential role of higher-intensity exercise to reduce CVD risk in this population.
《美国人身体活动指南》建议，无论心血管疾病（CVD）风险如何，每周至少进行150分钟的中等强度（MPA）至剧烈强度（VPA）身体活动以维持健康。本研究评估了身体活动（PA）强度是否能区分来自男性生殖表观基因组学研究的196名年龄在18至40岁的瘦型和肥胖西班牙裔男性的低CVD风险和高CVD风险。使用三轴加速度计测量7天的PA。计算30年的“完整”弗明汉风险评分（FRS）。使用健康饮食指数（HEI - 2020）评估饮食质量。平均年龄为30±5岁，FRS中位数为14%（范围：3%至85%）。高风险组（n = 89）的平均完整FRS为20.3%±11.1%，而低风险组（n = 107）为7.0%±3.6%（p <0.001）。两组均达到指南推荐的PA水平。然而，低风险组进行的VPA更多（25±20 vs 12±12分钟/天；p <0.001）。逻辑回归显示，在对吸烟、饮食、年龄和体重指数（BMI）进行调整后，每天每增加1分钟的VPA可使高CVD风险的几率降低4.4%（p = 0.007），而MPA并未显著预测CVD风险（p = 0.823）。逐步回归显示，吸烟状况、BMI、VPA和饮食解释了FRS方差的47.8%（p <0.001），而MPA被排除在外。总之，VPA而非MPA能显著区分年轻西班牙裔男性的低CVD风险和高CVD风险，突出了高强度运动在降低该人群CVD风险方面的潜在作用。
