Zhu Yongfa, Wang Xue, Liu Taihui, Fu Yongkang
College of Computer Science and Technology, Beihua University, Jilin, 132013, China.
Sci Rep. 2025 May 25;15(1):18266. doi: 10.1038/s41598-025-03124-2.
Semi-supervised learning (SSL) is an effective method for medical image segmentation as it alleviates the dependence on clinical pixel-level annotations. Among the SSL methods, pseudo-labels and consistency regularization play a key role as the dominant paradigm. However, current consistency regularization methods based on shared encoder structures are prone to trap the model in cognitive bias, which impairs the segmentation performance. Furthermore, traditional fixed-threshold-based pseudo-label selection methods lack the utilization of low-confidence pixels, making the model's initial segmentation capability insufficient, especially for confusing regions. To this end, we propose a multi-perspective dynamic consistency (MPDC) framework to mitigate model cognitive bias and to fully utilize the low-confidence pixels. Specially, we propose a novel multi-perspective collaborative learning strategy that encourages the sub-branch networks to learn discriminative features from multiple perspectives, thus avoiding the problem of model cognitive bias and enhancing boundary perception. In addition, we further employ a dynamic decoupling consistency scheme to fully utilize low-confidence pixels. By dynamically adjusting the threshold, more pseudo-labels are involved in the early stages of training. Extensive experiments on several challenging medical image segmentation datasets show that our method achieves state-of-the-art performance, especially on boundaries, with significant improvements.
半监督学习(SSL)是医学图像分割的一种有效方法,因为它减轻了对临床像素级标注的依赖。在SSL方法中,伪标签和一致性正则化作为主导范式发挥着关键作用。然而,当前基于共享编码器结构的一致性正则化方法容易使模型陷入认知偏差,这会损害分割性能。此外,传统的基于固定阈值的伪标签选择方法缺乏对低置信度像素的利用,导致模型的初始分割能力不足,尤其是对于混淆区域。为此,我们提出了一种多视角动态一致性(MPDC)框架,以减轻模型的认知偏差并充分利用低置信度像素。具体而言,我们提出了一种新颖的多视角协作学习策略,鼓励子分支网络从多个视角学习判别性特征,从而避免模型认知偏差问题并增强边界感知。此外,我们进一步采用动态解耦一致性方案来充分利用低置信度像素。通过动态调整阈值,更多的伪标签在训练早期被纳入。在几个具有挑战性的医学图像分割数据集上进行的大量实验表明,我们的方法取得了领先的性能,尤其是在边界方面,有显著的提升。