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深度学习技术在自动 MRI 心脏多结构分割与诊断中的应用:问题是否已解决?

Deep Learning Techniques for Automatic MRI Cardiac Multi-Structures Segmentation and Diagnosis: Is the Problem Solved?

出版信息

IEEE Trans Med Imaging. 2018 Nov;37(11):2514-2525. doi: 10.1109/TMI.2018.2837502. Epub 2018 May 17.

DOI:10.1109/TMI.2018.2837502
PMID:29994302
Abstract

Delineation of the left ventricular cavity, myocardium, and right ventricle from cardiac magnetic resonance images (multi-slice 2-D cine MRI) is a common clinical task to establish diagnosis. The automation of the corresponding tasks has thus been the subject of intense research over the past decades. In this paper, we introduce the "Automatic Cardiac Diagnosis Challenge" dataset (ACDC), the largest publicly available and fully annotated dataset for the purpose of cardiac MRI (CMR) assessment. The dataset contains data from 150 multi-equipments CMRI recordings with reference measurements and classification from two medical experts. The overarching objective of this paper is to measure how far state-of-the-art deep learning methods can go at assessing CMRI, i.e., segmenting the myocardium and the two ventricles as well as classifying pathologies. In the wake of the 2017 MICCAI-ACDC challenge, we report results from deep learning methods provided by nine research groups for the segmentation task and four groups for the classification task. Results show that the best methods faithfully reproduce the expert analysis, leading to a mean value of 0.97 correlation score for the automatic extraction of clinical indices and an accuracy of 0.96 for automatic diagnosis. These results clearly open the door to highly accurate and fully automatic analysis of cardiac CMRI. We also identify scenarios for which deep learning methods are still failing. Both the dataset and detailed results are publicly available online, while the platform will remain open for new submissions.

摘要

从心脏磁共振图像(多层 2D 电影 MRI)中描绘左心室腔、心肌和右心室是建立诊断的常见临床任务。因此,相应任务的自动化是过去几十年来研究的热点。在本文中,我们介绍了“自动心脏诊断挑战”(ACDC)数据集,这是最大的公开可用且完全注释的用于心脏 MRI(CMR)评估的数据集。该数据集包含来自 150 个多设备 CMRI 记录的数据,以及来自两位医学专家的参考测量和分类。本文的总体目标是衡量最先进的深度学习方法在评估 CMRI 方面的进展程度,即分割心肌和两个心室以及分类病理学。继 2017 年 MICCAI-ACDC 挑战赛之后,我们报告了来自九个研究小组的分割任务和四个小组的分类任务的深度学习方法的结果。结果表明,最佳方法忠实地再现了专家分析,导致临床指标的自动提取的平均相关分数为 0.97,自动诊断的准确性为 0.96。这些结果显然为心脏 CMRI 的高度准确和全自动分析开辟了道路。我们还确定了深度学习方法仍然失败的情况。数据集和详细结果均可在线获取,而该平台将继续开放新的提交。

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