Salit I E
CMAJ. 1985 Oct 1;133(7):659-63.
Outbreaks of epidemic neuromyasthenia have occurred throughout the world for many years, but sporadic cases have only recently been recognized. Fifty consecutive previously well patients with prolonged and excessive fatigue after an apparent acute infection were investigated. Most were well educated, active, unmarried women aged 30 to 40 years. The precipitating infection had many clinical presentations. The chronic phase of the illness was characterized by a fairly common set of symptoms. Physical examination and laboratory testing generally gave normal results. Of the 50 patients 16 were found to be infected with Epstein-Barr virus, 7 with other viruses, 4 with parasites and 2 with Mycoplasma pneumoniae. The causative agent was not known in 22 cases. The mean duration of the illness was 27.6 months, and the mean proportion of time lost from work or school was 39%. Drug therapy was not beneficial; supportive therapy was useful. Further investigation is required to determine optimal management of sporadic neuromyasthenia.
多年来，流行性神经肌无力已在世界各地爆发，但散发病例直到最近才被认识到。对50例连续的先前健康、在明显急性感染后出现长期过度疲劳的患者进行了调查。大多数是30至40岁、受过良好教育、活跃的未婚女性。引发感染有多种临床表现。疾病的慢性期以一组相当常见的症状为特征。体格检查和实验室检查结果通常正常。在这50例患者中，发现16例感染了爱泼斯坦-巴尔病毒，7例感染了其他病毒，4例感染了寄生虫，2例感染了肺炎支原体。22例患者的病原体不明。疾病的平均持续时间为27.6个月，平均误工或误学时间比例为39%。药物治疗无效；支持治疗有用。需要进一步调查以确定散发性神经肌无力的最佳管理方法。
