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干细胞与纳米材料的交叉领域:对组织工程和再生医学的影响

The Intersection of Stem Cells and Nanomaterials: Implications for Tissue Engineering and Regenerative Medicine.

作者信息

Hsu Chou-Yi, Abd Mariam Ayad, Merza Mohammed, Alkhathami Ali G, Ballal Suhas, Kalia Rishiv, Sabarivani A, Sahoo Samir, Hulail Hanen Mahmod

机构信息

Thunderbird School of Global Management, Arizona State University, Tempe Campus, Phoenix, AZ, 85004, USA.

Medical Laboratory Techniques department, College of Health and Medical Technology, University of Al-maarif, Anbar, Iraq.

出版信息

Stem Cell Rev Rep. 2025 May 27. doi: 10.1007/s12015-025-10897-6.

DOI:10.1007/s12015-025-10897-6
PMID:40423738
Abstract

An emerging field with great implications for therapeutics and regenerative medicine is nanomaterial in stem cell biology. The aim of this review is to explore the potential of nanomaterials in stem cell research, covering targeted delivery, differentiation and tracking. We will also present safety aspects related to the use of nanomaterials, highlighting the need to perform full toxicity, biocompatibility, and long-term assessment of their implications for tissues and stem cells in the vicinity of the scaffold.

摘要

纳米材料在干细胞生物学中是一个对治疗学和再生医学具有重大意义的新兴领域。本综述的目的是探讨纳米材料在干细胞研究中的潜力,涵盖靶向递送、分化和追踪。我们还将介绍与纳米材料使用相关的安全性问题,强调需要对其在支架附近组织和干细胞中的影响进行全面的毒性、生物相容性和长期评估。

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本文引用的文献

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Graphene Oxide promotes embryonic stem cell differentiation to haematopoietic lineage.氧化石墨烯促进胚胎干细胞向造血谱系分化。
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Generation of cortical neurons from human induced-pluripotent stem cells by biodegradable polymeric microspheres loaded with priming factors.通过负载启动因子的可生物降解聚合物微球从人诱导多能干细胞生成皮质神经元。
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Response of MAPK pathway to iron oxide nanoparticles in vitro treatment promotes osteogenic differentiation of hBMSCs.
丝裂原活化蛋白激酶(MAPK)信号通路对体外氧化铁纳米颗粒处理的反应促进人骨髓间充质干细胞(hBMSCs)的成骨分化。
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Improving the osteogenesis of rat mesenchymal stem cells by chitosan-based-microRNA nanoparticles.壳聚糖基 miRNA 纳米颗粒促进大鼠间充质干细胞成骨。
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Gold Nanoparticle-Decorated Scaffolds Promote Neuronal Differentiation and Maturation.金纳米粒子修饰支架促进神经元分化和成熟。
Nano Lett. 2016 May 11;16(5):2916-20. doi: 10.1021/acs.nanolett.5b04033. Epub 2015 Dec 19.
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Silver nanoparticles promote osteogenesis of mesenchymal stem cells and improve bone fracture healing in osteogenesis mechanism mouse model.银纳米粒子促进间充质干细胞成骨,并通过成骨机制改善骨愈合。
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Reprogramming fibroblasts to pluripotency using arginine-terminated polyamidoamine nanoparticles based non-viral gene delivery system.使用基于精氨酸末端聚酰胺胺纳米颗粒的非病毒基因递送系统将成纤维细胞重编程为多能性。
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Different endocytotic uptake mechanisms for nanoparticles in epithelial cells and macrophages.纳米颗粒在上皮细胞和巨噬细胞中有不同的内吞摄取机制。
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Differential regulation of osteogenic differentiation of stem cells on surface roughness gradients.表面粗糙度梯度对干细胞成骨分化的差异调控。
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3D bioprinting of tissues and organs.组织和器官的三维生物打印。
Nat Biotechnol. 2014 Aug;32(8):773-85. doi: 10.1038/nbt.2958.