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利用sp.进行绿色真菌合成氧化锌纳米颗粒：在生物医学应用中的肝脏保护、抗菌和抗氧化潜力

Green Myco-Synthesis of Zinc Oxide Nanoparticles Using sp.: Hepatoprotective, Antimicrobial, and Antioxidant Potential for Biomedical Applications.

作者信息

Fazal Uzma, Zada Ahmad, Hanif Muhammad, Lee Shiou Yih, Faisal Mohammad, Alatar Abdulrahman A, Sultana Tahira

机构信息

College of Bioscience and Biotechnology, Yangzhou University, Yangzhou 225009, China.

Department of Botany, Government College University, Lahore 54000, Pakistan.

出版信息

Microorganisms. 2025 Apr 22;13(5):956. doi: 10.3390/microorganisms13050956.

DOI:10.3390/microorganisms13050956
PMID:40431129
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12114609/
Abstract

The transformative effect of nanotechnology is revolutionizing medicine by introducing new therapeutic approaches. This study explores the utilization of aqueous extract from mushroom ( sp.) used as a reducing agent to prepare zinc oxide myco-nanoparticles (ZnO-MNPs) in an eco-friendly manner. The synthesis of ZnO-MNPs has been confirmed by various characterization studies, including UV-vis spectroscopy, which revealed an absorption peak at 378 nm; X-ray diffraction (XRD) analysis, which revealed a wurtzite hexagonal structure; and Fourier transform infrared spectra (FTIR), which showed stabilizing agents around the ZnO-MNPs. The effectiveness of ZnO-MNPs as an anti-cancer agent was evaluated by monitoring liver biochemical parameters against hepatotoxicity caused by carbon tetrachloride (CCl) in Balb C mice. The results showed that the levels of catalase, glutathione (GSH), and total protein were significantly lower, while alanine aminotransferase (ALT), aspartate aminotransferase (ASAT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), melanin dialdehyde (MDA), and total bilirubin (TB) were significantly higher in each of the CCl treatment groups. ZnO-MNP treatment significantly reduced the toxicological effects of CCl but did not completely restore the accumulation. The antimicrobial efficacy of ZnO-MNPs was investigated and showed potential results against common pathogens, including (29.05 ± 0.76), (27.05 ± 0.5), (23.36 ± 0.5), and (25.86 ± 0.80), while antifungal activity was relatively lower. Moreover, the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay showed that ZnO-MNPs are strong antioxidant agents. Overall, these findings highlight the effectiveness of myco-synthesized ZnO-NPs in combating pathogenic diseases, their promising role in cancer therapy, and their potential as a biomaterial option for future therapeutic applications.

摘要

纳米技术的变革作用正在通过引入新的治疗方法彻底改变医学。本研究探索了以蘑菇（种）水提取物作为还原剂，以环保方式制备氧化锌真菌纳米颗粒（ZnO - MNPs）的方法。通过各种表征研究证实了ZnO - MNPs的合成，包括紫外可见光谱，其显示在378nm处有吸收峰；X射线衍射（XRD）分析，其显示出纤锌矿六方结构；以及傅里叶变换红外光谱（FTIR），其显示ZnO - MNPs周围有稳定剂。通过监测Balb C小鼠中由四氯化碳（CCl）引起的肝毒性相关的肝脏生化参数，评估了ZnO - MNPs作为抗癌剂的有效性。结果表明，在每个CCl处理组中，过氧化氢酶、谷胱甘肽（GSH）和总蛋白水平显著降低，而丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（ASAT）、碱性磷酸酶（ALP）、乳酸脱氢酶（LDH）、丙二醛（MDA）和总胆红素（TB）显著升高。ZnO - MNP处理显著降低了CCl的毒理学效应，但未完全恢复其积累。研究了ZnO - MNPs的抗菌功效，结果表明其对常见病原体具有潜在效果，包括（29.05±0.76）、（27.05±0.5）、（23.36±0.5）和（25.86±0.80），而抗真菌活性相对较低。此外，2,2 - 二苯基 - 1 - 苦基肼（DPPH）测定表明ZnO - MNPs是强抗氧化剂。总体而言，这些发现突出了真菌合成的ZnO - NPs在对抗致病疾病方面的有效性及其在癌症治疗中的前景作用，以及其作为未来治疗应用生物材料选择的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c1/12114609/e1470a544591/microorganisms-13-00956-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c1/12114609/a5ad7f2c1f8a/microorganisms-13-00956-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c1/12114609/416dcb38c488/microorganisms-13-00956-g002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c1/12114609/70d24b039953/microorganisms-13-00956-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c1/12114609/569e78470601/microorganisms-13-00956-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c1/12114609/1cf5e6f54af9/microorganisms-13-00956-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c1/12114609/715de9d9e450/microorganisms-13-00956-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c1/12114609/e1470a544591/microorganisms-13-00956-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c1/12114609/a5ad7f2c1f8a/microorganisms-13-00956-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c1/12114609/416dcb38c488/microorganisms-13-00956-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c1/12114609/0474fa198c42/microorganisms-13-00956-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c1/12114609/3053266eaa9b/microorganisms-13-00956-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c1/12114609/70d24b039953/microorganisms-13-00956-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c1/12114609/569e78470601/microorganisms-13-00956-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c1/12114609/1cf5e6f54af9/microorganisms-13-00956-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c1/12114609/715de9d9e450/microorganisms-13-00956-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c1/12114609/e1470a544591/microorganisms-13-00956-g009.jpg

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