Hong Sang Hoon, Huh Jin, De Ranjit, Park RoWoon, Yang Seung Min, Choi Hyunsik, Jung Ho Sang, Hahn Sei Kwang
Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang, Gyeongbuk, 790-784, South Korea.
Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang, Gyeongbuk, 790-784, South Korea; School of Life Science, Handong Global University, Pohang, 37554, South Korea.
Biomaterials. 2025 Dec;323:123427. doi: 10.1016/j.biomaterials.2025.123427. Epub 2025 May 21.
Regenerative medicine with stem cells has played a pivotal role in tissue engineering, demonstrating remarkable potential to address degenerative diseases and tissue deficiencies. Despite its great potential, this field faces significant challenges, including the need to control cellular behavior, achieve real-time monitoring, and standardize stimulation protocols. To address these technical hurdles, the integration of stem cells with smart bioelectronic materials and devices has emerged as a groundbreaking paradigm in regenerative medicine, offering huge potential for improved therapeutic outcomes in various tissue engineering applications. In this review, we provide a comprehensive analysis of smart bioelectronic systems in regenerative medicine. It reviews recent advances in bioelectronic materials for cellular interfacing, functional device platforms, and real-time physiological monitoring and biophysical stimulation systems. Furthermore, it highlights how these technologies are applied in vascular, cardiac, neural, and bone tissue engineering to support the regeneration and functional integration. With representative case studies, this review underscores how regenerative bioelectronics enables dynamic, tissue-specific therapies across biomedical fields.
干细胞再生医学在组织工程中发挥了关键作用，显示出在解决退行性疾病和组织缺陷方面的巨大潜力。尽管具有巨大潜力，但该领域面临重大挑战，包括需要控制细胞行为、实现实时监测以及规范刺激方案。为克服这些技术障碍，干细胞与智能生物电子材料及设备的整合已成为再生医学中的一个开创性范例，在各种组织工程应用中为改善治疗效果提供了巨大潜力。在本综述中，我们对再生医学中的智能生物电子系统进行了全面分析。它回顾了用于细胞接口的生物电子材料、功能设备平台以及实时生理监测和生物物理刺激系统的最新进展。此外，它强调了这些技术如何应用于血管、心脏、神经和骨组织工程以支持再生和功能整合。通过代表性案例研究，本综述强调了再生生物电子学如何在生物医学领域实现动态的、组织特异性的治疗。
