Zhao Chuanwei, Yang Yane, Wang Yao, Lin Mu, Gao Chenxuan, Ni Huan, Gao Shizhen, Gao Zhengqian, Yang Haijie
Department of Cardiology, The Second People's Hospital of Baoshan, No. 13, Zhengyang (S) Rd., Longyang Dist., Baoshan, Yunnan, China.
Sci Rep. 2025 May 28;15(1):18725. doi: 10.1038/s41598-025-02169-7.
This study aimed to investigate the relationship between the Dietary Inflammatory Index (DII) and stroke prevalence in patients with diabetes. Data were collected from 9,914 diabetic patients who participated in the National Health and Nutrition Examination Survey (NHANES) between 1999 and 2020. Weighted multivariable logistic regression models were used to analyze the association between DII and stroke risk in diabetic patients, with restricted cubic spline (RCS) regression employed to test for nonlinear relationships. Subgroup analyses were conducted based on sex, age, race, BMI, smoking, alcohol consumption, hypertension, and coronary heart disease status. After adjusting for confounding factors, individuals in the highest DII quartile had a significantly higher risk of stroke compared to those in the lowest quartile, with an adjusted odds ratio (OR) of 1.78 (95% CI: 1.35,2.36). Additionally, each unit increase in DII was associated with a 13% increase in stroke risk (OR: 1.13, 95% CI: 1.06, 1.20). The RCS curve indicated a linear positive association between DII and stroke risk in diabetic patients. A linear positive association between DII and stroke risk was observed in patients with diabetes. Given the cross-sectional nature of the study, further research is required to establish causality.
本研究旨在调查饮食炎症指数（DII）与糖尿病患者中风患病率之间的关系。数据收集自1999年至2020年间参加美国国家健康与营养检查调查（NHANES）的9914名糖尿病患者。采用加权多变量逻辑回归模型分析DII与糖尿病患者中风风险之间的关联，并采用受限立方样条（RCS）回归检验非线性关系。根据性别、年龄、种族、体重指数、吸烟、饮酒、高血压和冠心病状况进行亚组分析。在调整混杂因素后，与最低四分位数的个体相比，DII最高四分位数的个体中风风险显著更高，调整后的优势比（OR）为1.78（95%置信区间：1.35,2.36）。此外，DII每增加一个单位，中风风险增加13%（OR：1.13，95%置信区间：1.06,1.20）。RCS曲线表明DII与糖尿病患者中风风险之间呈线性正相关。在糖尿病患者中观察到DII与中风风险之间呈线性正相关。鉴于本研究的横断面性质，需要进一步研究以确定因果关系。
