Ojasanya Rasaq A, Weese J Scott, Poljak Zvonimir, Sobkowich Kurtis E, Kukathasan Uththami, Bernardo Theresa M
Department of Population Medicine, Ontario Veterinary College, University of Guelph, Ontario, Canada.
Department of Pathobiology, Ontario Veterinary College, University of Guelph, Ontario, Canada.
PLoS One. 2025 May 30;20(5):e0323246. doi: 10.1371/journal.pone.0323246. eCollection 2025.
Pathogenic Escherichia coli causes a range of clinical manifestations in dogs and cats, and the use of antimicrobials in pets is associated with the risk of antimicrobial resistance (AMR). Pets contribute to the dissemination of AMR both within their species and to humans. This study conducts a scoping review to assess the existing evidence on the AMR of E. coli in dogs and cats, noting the purpose of antimicrobial susceptibility testing (AST) and determining the knowledge gaps to inform future research. The search utilized specific and generic strings aligned with the research objectives, spanning databases such as MEDLINE®, Web of Science, Biological Science Collection, AGRICOLA, CAB Direct, and Google Scholar, from January 1990 to July 2023. The study selection included only articles published in English and related to primary research. Following deduplication, the initial search identified 1,205 studies. After a detailed full-text review, 108 independent studies were identified. Studies on the AMR of E. coli in companion animals are largely concentrated in North America and Western Europe. Most of the studies were observational and were conducted in veterinary clinics. AST was primarily conducted to guide the antimicrobial treatment of E. coli infections in pets. Although not all studies provided clinical histories, among those that did, multi-drug resistant (MDR) E. coli was reported in both healthy and ailing pets. The detection of MDR E. coli in healthy and sick pets serve as a clarion call for antimicrobial stewardship. However, the limited number of studies dedicated to AMR monitoring and surveillance programs for companion animals raises a substantial concern.
致病性大肠杆菌可在犬猫身上引发一系列临床表现，而在宠物中使用抗菌药物与抗菌药物耐药性（AMR）风险相关。宠物在其物种内部以及向人类传播AMR方面都起到了作用。本研究进行了一项范围综述，以评估关于犬猫大肠杆菌AMR的现有证据，明确抗菌药物敏感性试验（AST）的目的，并确定知识空白，为未来研究提供信息。检索使用了与研究目标相符的特定和通用检索词，涵盖1990年1月至2023年7月期间的MEDLINE®、科学网、生物科学数据库、农业文献数据库、CAB Direct以及谷歌学术等数据库。研究选择仅包括以英文发表且与原始研究相关的文章。去重后，初步检索识别出1205项研究。经过详细的全文审查，确定了108项独立研究。关于伴侣动物大肠杆菌AMR的研究主要集中在北美和西欧。大多数研究为观察性研究，在兽医诊所进行。AST主要用于指导宠物大肠杆菌感染的抗菌治疗。尽管并非所有研究都提供了临床病史，但在提供了临床病史的研究中，健康和患病宠物均报告了多重耐药（MDR）大肠杆菌。在健康和患病宠物中检测到MDR大肠杆菌，为抗菌药物管理敲响了警钟。然而，专门针对伴侣动物AMR监测和监督项目的研究数量有限，这引发了人们的重大担忧。
