Hui Shiqi, Zhang Ju, Hou Zhijia, Li Dong-Mei
Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Aier Eye Hospital Group Co., Ltd. Beijing Aier Eye Hospital, Jinan University, Guangzhou, Guangdong, China.
Scientifica (Cairo). 2025 May 23;2025:1855515. doi: 10.1155/sci5/1855515. eCollection 2025.
To assess the correlation of upper eyelid retraction and the disease natural course of untreated thyroid eye disease patients, using multiple radial midpupil lid distance, for individualized eyelid morphological treatment. Semiautomatic photographic analysis was performed using ImageJ. Temporal/nasal multiple radial midpupil lid distance ratios of the same angles with respect to the midline was calculated. The influence of several variable factors on the asymmetrical upper eyelid retraction was evaluated. One hundred and fifty-one eyes of 85 untreated thyroid eye disease patients were included. The mean age of patients was 45.4 ± 14.7 years. Multiple radial midpupil lid distance ratios increased during the first 12 months, 105°/75° ( = 0.196, =0.087), 120°/60° ( = 0.250, =0.028), 135°/45° ( = 0.309, =0.006), and 150°/30° ( = 0.275, =0.015). The ratios then slowly decreased, 120°/60° ( = -0.332, =0.006), 135°/45° ( = -0.297, =0.014), and 150°/30° ( = -0.254, =0.037). The ratios plateaued at 13 months but were still greater than normal range. No correlation found between smoking history (=0.230), family history (=0.382), exophthalmometry (=0.597), and natural course. Women had a higher likelihood of upper eyelid retraction asymmetry, 120°/60° (=0.041) and 135°/45° (=0.048). The absence of systemic disease was associated with a lower likelihood of upper eyelid retraction asymmetry in 120°/60° (=0.036). No significant difference was found in the contralateral eye of unilateral patients. Multiple radial midpupil lid distance is a valuable method for measuring asymmetrical upper eyelid retraction, enabling improved understanding in upper eyelid contour with the duration of untreated thyroid eye disease. Allowing a better decision on individualized treatment.
为评估上睑退缩与未经治疗的甲状腺眼病患者疾病自然病程的相关性，采用多个放射状瞳孔中点睑裂距离进行个体化眼睑形态治疗。使用ImageJ进行半自动摄影分析。计算相对于中线相同角度的颞侧/鼻侧多个放射状瞳孔中点睑裂距离比值。评估了几个可变因素对不对称性上睑退缩的影响。纳入了85例未经治疗的甲状腺眼病患者的151只眼。患者的平均年龄为45.4±14.7岁。多个放射状瞳孔中点睑裂距离比值在最初12个月内增加，105°/75°（=0.196，=0.087），120°/60°（=0.250，=0.028），135°/45°（=0.309，=0.006），以及150°/30°（=0.275，=0.015）。然后这些比值缓慢下降，120°/60°（= -0.332，=0.006），135°/45°（= -0.297，=0.014），以及150°/30°（= -0.254，=0.037）。这些比值在13个月时趋于平稳，但仍高于正常范围。未发现吸烟史（=0.230）、家族史（=0.382）、眼球突出测量值（=0.597）与自然病程之间存在相关性。女性发生上睑退缩不对称的可能性更高，120°/60°（=0.041）和135°/45°（=0.048）。无全身性疾病与120°/60°上睑退缩不对称的可能性较低相关（=0.036）。单侧患者的对侧眼未发现显著差异。多个放射状瞳孔中点睑裂距离是测量不对称性上睑退缩的一种有价值的方法，有助于更好地了解未经治疗的甲状腺眼病病程中眼睑轮廓的变化。有助于对个体化治疗做出更好的决策。
