Kohno A, Yonezu T, Matsushita M, Irino M, Higuchi K, Higuchi K, Takeshita S, Hosokawa M, Takeda T
J Nutr. 1985 Oct;115(10):1259-66. doi: 10.1093/jn/115.10.1259.
The effects of chronic food restriction on grading scores of senescence, deposition of senile amyloid (ASSAM), mean life span and 10th decile were investigated by using animal models for accelerated senescence (SAM-P/1) and for normal aging (SAM-R/1). The experimental groups consisted of control (ad libitum fed), 80% (fed 80% of control intake), and 60% (fed 60% of control intake) groups. The grading score of SAM-P/1 mice was significantly improved in the 60% group, but not in the 80% group, compared to the control group. The grading score of SAM-R/1 mice, however, was significantly less than that in the control group in both the 60 and 80% groups. In SAM-P/1 mice liver, skin and testis, the severity of senile amyloid deposition was significantly less with 40% food restriction (60% group) than in the control group. A restriction of 20% (80% group) had no influence on amyloid deposition. A definite tendency to prolong mean life span (24.3%) and 10th decile (65.9%, mean life span of the last 10th of survivors of a group) was observed in the 60% group of SAM-P/1 mice, but the changes were not statistically significant. In the 80% group of SAM-P/1 mice and also in either restriction group of SAM-R/1 mice, however, such a tendency was not evident. These results indicate that 40% food restriction modulates the advance of senescence in these mice.
通过使用加速衰老动物模型（SAM-P/1）和正常衰老动物模型（SAM-R/1），研究了长期食物限制对衰老分级评分、老年淀粉样蛋白沉积（ASSAM）、平均寿命和第十百分位数的影响。实验组包括对照组（自由进食）、80%组（进食量为对照组摄入量的80%）和60%组（进食量为对照组摄入量的60%）。与对照组相比，SAM-P/1小鼠的分级评分在60%组有显著改善，但在80%组没有。然而，SAM-R/1小鼠的分级评分在60%组和80%组均显著低于对照组。在SAM-P/1小鼠的肝脏、皮肤和睾丸中，40%食物限制（60%组）时老年淀粉样蛋白沉积的严重程度明显低于对照组。20%的限制（80%组）对淀粉样蛋白沉积没有影响。在SAM-P/1小鼠的60%组中观察到有延长平均寿命（24.3%）和第十百分位数（65.9%，一组中最后十分之一存活者的平均寿命）的明确趋势，但这些变化没有统计学意义。然而，在SAM-P/1小鼠的80%组以及SAM-R/1小鼠的任何一个限制组中，这种趋势都不明显。这些结果表明，40%的食物限制可调节这些小鼠的衰老进程。
