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用于高效姜黄素递送的磁性纳米载体——磁铁矿-壳聚糖包覆的铁基金属有机框架（FeO@壳聚糖/MIL-100(Fe)）的设计、制备与表征

Design, fabrication and characterization of a magnetite-chitosan coated iron-based metal-organic framework (FeO@chitosan/MIL-100(Fe)) for efficient curcumin delivery as a magnetic nanocarrier.

作者信息

Parsa Fatemeh, Setoodehkhah Moslem, Atyabi Seyed Mohammad

机构信息

Department of Inorganic Chemistry, Faculty of Chemistry, University of Kashan Kashan Iran

PhD Department of Pilot Biotechnology Pasteur Institute of Iran Tehran Iran.

出版信息

RSC Adv. 2025 Jun 3;15(23):18518-18534. doi: 10.1039/d5ra00162e. eCollection 2025 May 29.

DOI:10.1039/d5ra00162e
PMID:40463349
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12132104/
Abstract

Curcumin, a natural polyphenol with potent anticancer and anti-inflammatory properties, has significant limitations in biomedical applications due to its poor water solubility, rapid metabolism, and low bioavailability. To overcome these challenges, drug delivery systems such as metal-organic frameworks (MOFs) have been explored. This study developed a magnetic nanocomposite, FeO@chitosan/MIL-100(Fe), designed to enhance curcumin delivery. The nanocomposite consists of a magnetic FeO core coated with biocompatible chitosan, which facilitates MOF (MIL-100(Fe)) growth, improving drug-loading capacity and targeted delivery potential. Different ratios of magnetite-coated chitosan to MOF were evaluated, with the optimal 1 : 1 ratio achieving an exceptional drug loading efficiency (DLE) of 95.36% within 24 hours and a drug loading content (DLC) of 48.81%. Brunauer-Emmett-Teller (BET) and EDX-mapping analyses confirmed that curcumin was effectively encapsulated within the nanocomposite's porous structure and uniformly adsorbed on its surface. Adsorption studies indicated that curcumin adsorption followed the Freundlich isotherm model, while kinetic analysis showed strong agreement with the intraparticle diffusion and Korsmeyer-Peppas models. Notably, the curcumin-loaded FeO@CS/MIL-100(Fe) demonstrated greater cytotoxicity against breast cancer cells (MCF-7) than free curcumin and the unloaded nanocarrier while exhibiting lower toxicity toward normal human dermal fibroblast (HDF) cells, as confirmed by MTT assays. These findings suggest that FeO@CS/MIL-100(Fe) offers a promising strategy to overcome curcumin's inherent limitations, paving the way for more effective targeted drug delivery systems.

摘要

姜黄素是一种具有强大抗癌和抗炎特性的天然多酚，由于其水溶性差、代谢快和生物利用度低，在生物医学应用中存在显著局限性。为了克服这些挑战，人们探索了诸如金属有机框架（MOF）等药物递送系统。本研究开发了一种磁性纳米复合材料FeO@壳聚糖/MIL-100(Fe)，旨在增强姜黄素的递送。该纳米复合材料由包覆有生物相容性壳聚糖的磁性FeO核组成，壳聚糖有助于MOF（MIL-100(Fe)）生长，提高药物负载能力和靶向递送潜力。评估了磁铁矿包覆壳聚糖与MOF的不同比例，最佳的1:1比例在24小时内实现了95.36%的优异药物负载效率（DLE）和48.81%的药物负载量（DLC）。Brunauer-Emmett-Teller（BET）和EDX映射分析证实，姜黄素有效地包裹在纳米复合材料的多孔结构中，并均匀地吸附在其表面。吸附研究表明，姜黄素的吸附遵循Freundlich等温线模型，而动力学分析表明与颗粒内扩散和Korsmeyer-Peppas模型高度吻合。值得注意的是，MTT分析证实，负载姜黄素的FeO@CS/MIL-100(Fe)对乳腺癌细胞（MCF-7）的细胞毒性比游离姜黄素和未负载的纳米载体更大，而对正常人皮肤成纤维细胞（HDF）的毒性更低。这些发现表明，FeO@CS/MIL-100(Fe)为克服姜黄素的固有局限性提供了一种有前景的策略，为更有效的靶向药物递送系统铺平了道路。

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本文引用的文献

1
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Heliyon. 2024 Apr 25;10(9):e30349. doi: 10.1016/j.heliyon.2024.e30349. eCollection 2024 May 15.
2
Formulation of lactoferrin decorated dextran based chitosan-coated europium metal-organic framework for targeted delivery of curcumin.乳铁蛋白修饰的葡聚糖基壳聚糖包裹的铕金属有机框架的配方用于姜黄素的靶向递送。
Int J Biol Macromol. 2024 Feb;259(Pt 2):129325. doi: 10.1016/j.ijbiomac.2024.129325. Epub 2024 Jan 12.
3
pH-responsive nanogels with enhanced antioxidant and antitumor activities on drug delivery and smart drug release.
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Int J Biol Macromol. 2024 Feb;257(Pt 1):128590. doi: 10.1016/j.ijbiomac.2023.128590. Epub 2023 Dec 4.
4
The effect of synthesis conditions on the in situ grown MIL-100(Fe)-chitosan beads: Interplay between structural properties and arsenic adsorption.合成条件对原位生长的MIL-100(Fe)-壳聚糖微球的影响：结构性质与砷吸附之间的相互作用
J Hazard Mater. 2024 Feb 5;463:132893. doi: 10.1016/j.jhazmat.2023.132893. Epub 2023 Oct 31.
5
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6
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Nanomaterials (Basel). 2022 Dec 19;12(24):4494. doi: 10.3390/nano12244494.
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RSC Adv. 2020 Dec 22;10(73):45130-45138. doi: 10.1039/d0ra08459j. eCollection 2020 Dec 17.
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