Tabaru Alper, Rüzgar Sedat
Department of Otolaryngology University of Health Sciences Istanbul Turkey.
Department of Otolaryngology Bağcılar Training and Research Hospital Istanbul Turkey.
Laryngoscope Investig Otolaryngol. 2025 Jun 4;10(3):e70153. doi: 10.1002/lio2.70153. eCollection 2025 Jun.
This study aimed to examine the effect of topical oil (NSO) on intraoral wound healing in rats.
Forty-eight female Wistar albino rats (2.5-3 months old) were assigned to two groups ( = 24 each): A control group receiving no treatment and an NSO group receiving a topical application of 1 cc NSO. A standardized circular full-thickness wound (3 mm in diameter) was created on the mucoperiosteum of the hard palate. The animals were sacrificed on postoperative Days 3, 7, 14, and 20 to assess wound area macroscopically, wound diameter histologically, and immunohistochemically for anti-transforming growth factor-β (anti-TGF-β) and anti-vascular growth factor (anti-VGF).
No significant differences were observed between groups on days 3 and 20 ( > 0.05). On Days 7 and 14, however, the NSO group exhibited significantly smaller wound areas and wound diameters ( < 0.05). Immunohistochemical staining showed lower TGF-β expression on Days 7 and 14 in the NSO group compared to control ( < 0.05), whereas VGF staining did not differ significantly ( > 0.05).
Topical NSO accelerated the healing of intraoral wounds, particularly by enhancing re-epithelialization between postoperative days 7 and 14. This effect appears to be mediated through TGF-β modulation and NSO's known anti-inflammatory, antimicrobial, and antioxidant actions. Topical NSO may thus be considered as an adjunct to conventional wound management in the oral cavity.
NA.
本研究旨在探讨局部应用天然芝麻油（NSO）对大鼠口腔内伤口愈合的影响。
将48只雌性Wistar白化大鼠（2.5 - 3个月龄）分为两组（每组 = 24只）：一组为未接受治疗的对照组，另一组为局部应用1 cc NSO的NSO组。在硬腭的黏骨膜上制作一个标准化的圆形全层伤口（直径3 mm）。在术后第3、7、14和20天处死动物，以宏观评估伤口面积、组织学评估伤口直径，并通过免疫组织化学方法检测抗转化生长因子-β（抗TGF-β）和抗血管生长因子（抗VGF）。
在第3天和第20天，两组之间未观察到显著差异（P > 0.05）。然而，在第7天和第14天，NSO组的伤口面积和伤口直径明显较小（P < 0.05）。免疫组织化学染色显示，与对照组相比，NSO组在第7天和第14天的TGF-β表达较低（P < 0.05），而VGF染色无显著差异（P > 0.05）。
局部应用NSO可加速口腔内伤口的愈合，特别是在术后第7天至第14天通过促进上皮再形成来实现。这种作用似乎是通过TGF-β调节以及NSO已知的抗炎、抗菌和抗氧化作用介导的。因此，局部应用NSO可被视为口腔传统伤口处理的辅助方法。
无。
