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Cefazolin Is the Most Effective Perioperative Antibiotic to Prevent Periprosthetic Joint Infection.头孢唑林是预防人工关节周围感染最有效的围手术期抗生素。
Arthroplast Today. 2025 May 10;33:101708. doi: 10.1016/j.artd.2025.101708. eCollection 2025 Jun.
2
Non-cefazolin antibiotic prophylaxis is associated with higher rates of elbow periprosthetic joint infection.非头孢唑林抗生素预防与肘关节假体周围感染的较高发生率相关。
J Shoulder Elbow Surg. 2024 Apr;33(4):940-947. doi: 10.1016/j.jse.2023.10.029. Epub 2023 Dec 15.
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Cefazolin Prophylaxis for Total Joint Arthroplasty: Obese Patients Are Frequently Underdosed and at Increased Risk of Periprosthetic Joint Infection.头孢唑林预防全关节置换术：肥胖患者经常剂量不足，且有增加假体周围关节感染的风险。
J Arthroplasty. 2018 Nov;33(11):3551-3554. doi: 10.1016/j.arth.2018.06.037. Epub 2018 Jul 5.
4
Cefazolin remains the linchpin for preventing acute periprosthetic joint infection following primary total knee arthroplasty.头孢唑林仍然是初次全膝关节置换术后预防急性人工关节周围感染的关键药物。
Bone Jt Open. 2022 Jan;3(1):35-41. doi: 10.1302/2633-1462.31.BJO-2021-0051.R1.
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2019 John Charnley Award: Increased risk of prosthetic joint infection following primary total knee and hip arthroplasty with the use of alternative antibiotics to cefazolin: the value of allergy testing for antibiotic prophylaxis.2019 年约翰·查恩利奖：与使用头孢唑啉以外的抗生素相比，初次全膝关节和髋关节置换术后假体关节感染风险增加：抗生素预防过敏测试的价值。
Bone Joint J. 2019 Jun;101-B(6_Supple_B):9-15. doi: 10.1302/0301-620X.101B6.BJJ-2018-1407.R1.
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Antibiotic Prophylaxis with Cefazolin Is Associated with Lower Shoulder Periprosthetic Joint Infection Rates Than Non-Cefazolin Alternatives.头孢唑林预防性应用与非头孢唑林替代方案相比，可降低肩部人工关节周围感染率。
J Bone Joint Surg Am. 2022 May 18;104(10):872-880. doi: 10.2106/JBJS.21.00445. Epub 2022 Feb 21.
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Cefazolin Is Associated With a Lower Periprosthetic Joint Infection Risk than Alternative Antibiotic Regimens Following Total Hip Arthroplasty.在全髋关节置换术后，与其他抗生素治疗方案相比，头孢唑林与更低的人工关节周围感染风险相关。
J Arthroplasty. 2025 Oct;40(10):2671-2678. doi: 10.1016/j.arth.2025.04.079. Epub 2025 May 6.
8
Perioperative Antibiotic Prophylaxis: Single and 24-Hour Antibiotic Dosages are Equally Effective at Preventing Periprosthetic Joint Infection in Total Joint Arthroplasty.围手术期抗生素预防：单次和 24 小时抗生素剂量在预防全膝关节置换术后假体周围关节感染方面同样有效。
J Arthroplasty. 2021 Jul;36(7S):S308-S313. doi: 10.1016/j.arth.2021.02.037. Epub 2021 Feb 19.
9
The financial burden of vancomycin as an alternative to cefazolin for periprosthetic joint infection prophylaxis in total knee arthroplasty.万古霉素替代头孢唑林用于全膝关节置换术中假体周围关节感染预防的经济负担。
Arch Orthop Trauma Surg. 2025 Apr 26;145(1):272. doi: 10.1007/s00402-025-05879-9.
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Vancomycin Prophylaxis for Total Joint Arthroplasty: Incorrectly Dosed and Has a Higher Rate of Periprosthetic Infection Than Cefazolin.全关节置换术的万古霉素预防：剂量错误且假体周围感染率高于头孢唑林。
Clin Orthop Relat Res. 2017 Jul;475(7):1767-1774. doi: 10.1007/s11999-017-5302-0.

本文引用的文献

1
Preoperative Prophylactic Antibiotics in Total Hip and Knee Arthroplasty: What, When, and How.髋关节和膝关节置换术的术前预防性抗生素：用什么，何时用，如何用。
J Arthroplasty. 2022 Aug;37(8):1432-1434. doi: 10.1016/j.arth.2022.01.019. Epub 2022 Jan 17.
2
2019 John Charnley Award: Increased risk of prosthetic joint infection following primary total knee and hip arthroplasty with the use of alternative antibiotics to cefazolin: the value of allergy testing for antibiotic prophylaxis.2019 年约翰·查恩利奖：与使用头孢唑啉以外的抗生素相比，初次全膝关节和髋关节置换术后假体关节感染风险增加：抗生素预防过敏测试的价值。
Bone Joint J. 2019 Jun;101-B(6_Supple_B):9-15. doi: 10.1302/0301-620X.101B6.BJJ-2018-1407.R1.
3
Cefazolin Prophylaxis for Total Joint Arthroplasty: Obese Patients Are Frequently Underdosed and at Increased Risk of Periprosthetic Joint Infection.头孢唑林预防全关节置换术：肥胖患者经常剂量不足，且有增加假体周围关节感染的风险。
J Arthroplasty. 2018 Nov;33(11):3551-3554. doi: 10.1016/j.arth.2018.06.037. Epub 2018 Jul 5.
4
A Proactive Approach to Penicillin Allergy Testing in Hospitalized Patients.对住院患者进行青霉素过敏试验的积极方法。
J Allergy Clin Immunol Pract. 2017 May-Jun;5(3):686-693. doi: 10.1016/j.jaip.2016.09.045. Epub 2016 Nov 23.
5
The Current State of Screening and Decolonization for the Prevention of Staphylococcus aureus Surgical Site Infection After Total Hip and Knee Arthroplasty.全髋关节和膝关节置换术后预防金黄色葡萄球菌手术部位感染的筛查与去定植现状
J Bone Joint Surg Am. 2015 Sep 2;97(17):1449-58. doi: 10.2106/JBJS.N.01114.
6
Timing of surgical antibiotic prophylaxis and the risk of surgical site infection.手术抗生素预防的时机与手术部位感染的风险。
JAMA Surg. 2013 Jul;148(7):649-57. doi: 10.1001/jamasurg.2013.134.
7
Does dual antibiotic prophylaxis better prevent surgical site infections in total joint arthroplasty?双抗生素预防方案是否能更好地预防全关节置换术后的手术部位感染？
Clin Orthop Relat Res. 2012 Oct;470(10):2702-7. doi: 10.1007/s11999-012-2255-1.
8
The use of cephalosporins in penicillin-allergic patients: a literature review.青霉素过敏患者中头孢菌素的使用：文献综述
J Emerg Med. 2012 May;42(5):612-20. doi: 10.1016/j.jemermed.2011.05.035. Epub 2011 Jul 13.

Cefazolin Is the Most Effective Perioperative Antibiotic to Prevent Periprosthetic Joint Infection.

作者信息

Hannon Charles P, Wyles Cody C

出版信息

Arthroplast Today. 2025 May 10;33:101708. doi: 10.1016/j.artd.2025.101708. eCollection 2025 Jun.

DOI:10.1016/j.artd.2025.101708
PMID:40475007
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12139477/
Abstract
摘要