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肝病学中人工智能的挑战与未来展望:突破障碍,实现更好的治疗。

Challenges and Future Perspectives for Artificial Intelligence in Hepatology: Breaking Barriers for Better Care.

作者信息

Kusztos Victoria E, Simonetto Douglas A

机构信息

Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.

出版信息

J Clin Exp Hepatol. 2025 Sep-Oct;15(5):102579. doi: 10.1016/j.jceh.2025.102579. Epub 2025 Apr 14.

DOI:10.1016/j.jceh.2025.102579
PMID:40475117
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12136794/
Abstract

Artificial intelligence (AI) presents a compelling opportunity to revolutionize the practice of hepatology through a myriad of novel approaches ranging from predictive modeling to patient-specific clinical decision support systems. While AI will undoubtedly transform clinical practice in the coming years, there remains an evolving set of challenges to the implementation of AI. In this review article, we address technical and stakeholder barriers to the adoption of AI and potential repercussions if they remain unaddressed. We highlight strategies to mitigate these potential pitfalls and the need for prospective research to confirm model validity. Lastly, we look to the future of what AI in clinical practice will mean for patients and clinicians.

摘要

人工智能(AI)提供了一个极具吸引力的机会,可通过从预测建模到针对特定患者的临床决策支持系统等众多新颖方法,彻底改变肝病学的实践。虽然人工智能无疑将在未来几年改变临床实践,但在人工智能的实施方面仍存在一系列不断演变的挑战。在这篇综述文章中,我们探讨了采用人工智能的技术和利益相关者障碍,以及如果这些障碍得不到解决可能产生的影响。我们强调了减轻这些潜在陷阱的策略以及进行前瞻性研究以确认模型有效性的必要性。最后,我们展望临床实践中的人工智能对患者和临床医生意味着什么的未来。

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J Clin Exp Hepatol. 2025 Sep-Oct;15(5):102579. doi: 10.1016/j.jceh.2025.102579. Epub 2025 Apr 14.
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本文引用的文献

1
Generative AI for synthetic data across multiple medical modalities: A systematic review of recent developments and challenges.用于多种医学模态合成数据的生成式人工智能:近期发展与挑战的系统综述
Comput Biol Med. 2025 May;189:109834. doi: 10.1016/j.compbiomed.2025.109834. Epub 2025 Mar 1.
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Detecting and Mitigating the Clever Hans Effect in Medical Imaging: A Scoping Review.检测与减轻医学成像中的聪明汉斯效应:一项范围综述
J Imaging Inform Med. 2024 Nov 25. doi: 10.1007/s10278-024-01335-z.
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Advancing non-alcoholic fatty liver disease prediction: a comprehensive machine learning approach integrating SHAP interpretability and multi-cohort validation.
推进非酒精性脂肪性肝病预测:一种综合机器学习方法,整合 SHAP 可解释性和多队列验证。
Front Endocrinol (Lausanne). 2024 Oct 8;15:1450317. doi: 10.3389/fendo.2024.1450317. eCollection 2024.
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Artificial Intelligence to Predict Billing Code Levels of Emergency Department Encounters.人工智能预测急诊科就诊的计费代码级别
Ann Emerg Med. 2025 Jan;85(1):63-73. doi: 10.1016/j.annemergmed.2024.07.011. Epub 2024 Sep 24.
5
HEAR-MHE study: Automated speech analysis identifies minimal hepatic encephalopathy and may predict future overt hepatic encephalopathy.HEAR-MHE研究:自动语音分析可识别轻微肝性脑病,并可能预测未来显性肝性脑病。
Hepatology. 2025 Jun 1;81(6):1740-1752. doi: 10.1097/HEP.0000000000001086. Epub 2024 Sep 12.
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Artificial Intelligence and the Future of Gastroenterology and Hepatology.人工智能与胃肠病学和肝病学的未来
Gastro Hep Adv. 2022 May 11;1(4):581-595. doi: 10.1016/j.gastha.2022.02.025. eCollection 2022.
7
Development of a non-invasive diagnostic model for high-risk esophageal varices based on radiomics of spleen CT.基于脾脏 CT 影像组学构建非侵入性诊断高危食管静脉曲张模型
Abdom Radiol (NY). 2024 Dec;49(12):4373-4382. doi: 10.1007/s00261-024-04509-z. Epub 2024 Aug 3.
8
Design, implementation, and impact of a cirrhosis-specific remote patient monitoring program.肝硬化患者远程监测项目的设计、实施及影响。
Hepatol Commun. 2024 Jul 22;8(8). doi: 10.1097/HC9.0000000000000498. eCollection 2024 Aug 1.
9
A deep-learning-based model for assessment of autoimmune hepatitis from histology: AI(H).一种基于深度学习的组织学评估自身免疫性肝炎的模型:AI(H)。
Virchows Arch. 2024 Dec;485(6):1095-1105. doi: 10.1007/s00428-024-03841-5. Epub 2024 Jun 15.
10
TRIPOD+AI statement: updated guidance for reporting clinical prediction models that use regression or machine learning methods.TRIPOD+AI 声明:报告使用回归或机器学习方法的临床预测模型的更新指南。
BMJ. 2024 Apr 16;385:e078378. doi: 10.1136/bmj-2023-078378.