Takabayashi Masayuki, Yahata Yoshio, Handa Keisuke, Kyaw Moe Sandar, Suresh Venkata Venkataih, Saito Masahiro
Division of Operative Dentistry, Department of Ecological Dentistry, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan.
Division of Molecular Biology and Oral Biochemistry, Department of Oral Science, Graduate School of Dentistry, Kanagawa Dental University, 82 Inaoka-cho, Yokosuka, Kanagawa 238-8580, Japan.
Regen Ther. 2025 May 13;30:20-30. doi: 10.1016/j.reth.2025.04.007. eCollection 2025 Dec.
This study evaluated the efficacy of a resorbable l-lactide-ε-caprolactone copolymer (PLCL) membrane in promoting epithelial healing and preserving alveolar bone morphology using the open healing approach (OHA), compared to conventional membranes.
Extraction sockets in beagle dogs were filled with bone substitute material and covered with different membranes. Healing was assessed via histological analysis and micro-CT imaging.
The PLCL membrane reduced bone resorption and preserved alveolar bone morphology better than conventional membranes. Histological analysis showed excellent epithelial healing and notable bone formation.
The PLCL membrane effectively prevents infection, supports epithelial healing, and preserves alveolar bone morphology in OHA procedures.
本研究评估了一种可吸收的左旋丙交酯-ε-己内酯共聚物（PLCL）膜在使用开放愈合方法（OHA）促进上皮愈合和保留牙槽骨形态方面的疗效，并与传统膜进行了比较。
在比格犬的拔牙窝中填充骨替代材料，并用不同的膜覆盖。通过组织学分析和显微CT成像评估愈合情况。
与传统膜相比，PLCL膜能更好地减少骨吸收并保留牙槽骨形态。组织学分析显示上皮愈合良好且有显著的骨形成。
PLCL膜在OHA手术中能有效预防感染，支持上皮愈合并保留牙槽骨形态。
