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通过在双重感染的蚊子(三带喙库蚊)中进行基因组重配,布尼亚病毒的进化。

Evolution of bunyaviruses by genome reassortment in dually infected mosquitoes (Aedes triseriatus).

作者信息

Beaty B J, Sundin D R, Chandler L J, Bishop D H

出版信息

Science. 1985 Nov 1;230(4725):548-50. doi: 10.1126/science.4048949.

DOI:10.1126/science.4048949
PMID:4048949
Abstract

Aedes triseriatus mosquitoes became dually infected after ingesting two mutants of LaCrosse (LAC) virus simultaneously or after ingesting, by interrupted feeding, the two viruses sequentially within a 2-day period. After 2 weeks of incubation, approximately 25 percent of the vectors contained new virus genotypes as the result of RNA segment reassortment. New viruses were transmitted when the mosquitoes fed on mice. Viruses ingested more than 2 days after the initial infecting virus did not cause superinfection of the mosquito vectors.

摘要

三带喙库蚊在同时摄入两种拉克罗斯(LAC)病毒突变体后,或在2天内通过间断喂食依次摄入这两种病毒后会发生双重感染。经过2周的潜伏期,约25%的媒介因RNA片段重配而含有新的病毒基因型。当这些蚊子叮咬小鼠时,新病毒会传播。在最初感染病毒2天之后摄入的病毒不会导致蚊媒发生重复感染。

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