Chapagain Sudeep, Basnet Prabina, Khanal Surendra, Rabeeah Zahraa, Atemnkeng Njika
Internal Medicine, Piedmont Athens Regional Medical Center, Athens, USA.
Cureus. 2025 May 9;17(5):e83786. doi: 10.7759/cureus.83786. eCollection 2025 May.
Acute generalized exanthematous pustulosis (AGEP) is an extremely rare condition that is mostly caused by antibiotic exposure. Clinically, it manifests as the rapid appearance of multiple sterile pustules, swelling, and erythema within a few hours to days of exposure to the offending medication. Skin lesions usually resolve by desquamation after discontinuation of the offending agent. We present a case of a 58-year-old female patient with AGEP in the setting of piperacillin-tazobactam use, which was confirmed by histopathology with findings of neutrophilic pustules and eosinophilic infiltration. Her symptoms started resolving within three days of stopping the medication.
急性泛发性脓疱病（AGEP）是一种极为罕见的病症，主要由接触抗生素引起。临床上，它表现为在接触致病药物后的数小时至数天内迅速出现多个无菌脓疱、肿胀和红斑。停用致病药物后，皮肤病变通常通过脱屑而消退。我们报告一例58岁女性患者，在使用哌拉西林-他唑巴坦的情况下发生了AGEP，经组织病理学检查发现嗜中性脓疱和嗜酸性粒细胞浸润而得以确诊。她的症状在停药三天内开始缓解。
